A bstract Aim To compare and evaluate the shear bond strength of sixth and seventh-generation dentin bonding agents. Materials and methods Around 75 extracted permanent mandibular premolars were selected and assigned into two groups. The samples were cleaned, cavities were prepared, and the bonding agent was applied and stored in distilled water for 24 hours. Shear bond strength testing was done using a universal testing machine at the crosshead speed of 1 mm/minute. Data were analyzed statistically by one-way analysis of variance (ANOVA) and paired test. Results The greatest mean shear bond strength to dentin was exhibited by the sixth-generation dentin bonding agent due to the solvent present, which has a low concentration and low hydrophilicity than the seventh-generation. Conclusion Sixth-generation adhesives showed significantly higher mean shear bond strength to dentin than seventh-generation adhesives. Clinical significance Bond strength values are gross assessing tools for evaluating the efficacy of restorative bonding materials to dentin. And as the shear bond strength is less technique sensitive to perform, it will highlight the strength at the bonded interface. How to cite this article Adyanthaya BR, Gazal S, Mathur M, et al. To Compare and Evaluate the Shear Bond Strength of Sixth- and Seventh-generation Bonding Agents. Int J Clin Pediatr Dent 2022;15(5):525-528.