Parry-Romberg Syndrome, also known as Progressive Hemifacial Atrophy, is an uncommon degenerative condition, characterized by a slow and progressive atrophy affecting one side of the face. A cerebral disturbance of fat metabolism, atrophic malformation of Cervical Sympathetic Nervous System has been proposed as the primary cause. Other possible factors that are involved in the pathogenesis include trauma,viral infections, heredity, endocrine disturbances and auto-immunity. The objective of this work is, to accomplish a literature review concerning general characteristics, etiology, physiopathology, differential diagnosis and treatment of progressive hemifacial atrophy. A review of literature with variety of treatment options have been discussed in an attempt to treat the atrophic deformties from mild to severe cases. These have included free fat grafts, dermis fat grafts, fascia,muscle grafts, cartilage and bone augmentation ,Orthognathic surgery,microvascular reconstruction and stem cell regeneration of bone and soft tissues.

Odontogenic keratocyst is one of the most aggressive odontogenic cysts with a high recurrence rate, this was explained histopathologically as it typically shows a thin, friable wall, which is often difficult to enucleate from the bone in one piece, and have small satellite cysts within the fibrous wall. Multiple surgical approaches were introduced including decompression, marsupilization, enucleation with or without adjunct (Carnoy's solution, enucleation) and resection. Depending on other studies KCOT can be conservatively treated with enucleation and application of Carnoy's solution or cryotherapy. This can be used specially in the large lesions that when treated with resection, the continuity of the jaw will be interrupted. This technique shows comparable results to other more aggressive techniques.

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