In this paper, we study an area localization problem in large scale underwater wireless sensor networks (UWSNs). The limited bandwidth, the severely impaired channel and the cost of underwater equipment all make the underwater localization problem very challenging. Exact localization is very difficult for UWSNs in deep underwater environment. We propose a range free method based on mobile detachable elevator transceiver (DET) and 3D multi-power area localization scheme (3D-MALS) to address the challenging problem. In the proposed scheme, the ideas of 2D multi-power area localization scheme (2D-ALS) and utilizing DET are used to achieve the simplicity, location accuracy, scalability and low cost performances. The DET can rise and get down to broadcast its position. And it is assumed that all the underwater nodes underwater have pressure sensors and know their z coordinates. We evaluate the performances of 2D-ALS and our proposed 3D-MALS schemes under both ideal and non-ideal channel propagation conditions, in terms of localization error and localization ratio. The simulation results show that our proposed scheme is much more efficient than the 2D-ALS.

Based on differences in the response to GR-46611 in saline vs acid infused, spinal cord injured animals it is tempting to speculate that 2 distinct populations of bladder afferent C fibers (1 chemosensitive and 1 mechanosensitive) can initiate spinal bladder reflexes. Because 5-hydroxytryptamine(1A) receptor agonists increased bladder capacity under saline or acid infused conditions, they are promising candidates for decreasing bladder hyperactivity and increasing bladder capacity in patients with chronic spinal cord injury.

Efficient voiding in rats depends on a spinal pattern generator causing EUS motor neuron firing to occur in bursts, resulting in rapid urethral contraction and relaxation. Intrathecal kappa-2-opiate receptor agonists suppress this pattern generator, decreasing the number of bursts occurring during each micturition without decreasing motor neuron spike frequency during individual bursts or during tonic spike activity associated with urethral closure. Resultant dyssynergia leads to decreased voiding efficiency. The relevance of kappa-2 opioid receptors should be explored in higher species, especially regarding spinal cord injury induced dyssynergia.