Implantable central and peripheral neural interfaces have great potential in treating various nerve injuries and diseases. Still, limitations of surgery trauma, handling inconvenience, and biocompatibility issues of available materials and techniques significantly hinder the peripheral nerve interface for research and clinical purposes. MXenes have great potential as bioelectronics materials for excellent hydrophilicity, conductivity, and biocompatibility. However, their application in bioelectronic interface has been limited due to the poor oxidation stability and fast tissue clearance. Here, we developed a minimal-invasive jet-injected neural interface using MXene nanosheets with strong redox stability, tissue adhesion, conductivity, and good self-bonding properties. We also develop a minimal-invasive jet injector to implant the optimized MXene suspension into the damaged sciatic nerve and establish a neural interface through tissue adhesion and self-bonding. We use this neural interface to promote nerve regeneration and perform electrophysiology recording on moving mice. We prove that the nanosheets can mitigate cellular inflammation, promote tissue healing, and record high-quality electrophysiology signals for predicting joint movement. Thus, our material and implantation strategy together form a novel minimal-invasive neural interface, facilitating the collection and analysis of large-scale living body data to solve the challenge of neurological diseases of the peripheral or even the central nervous system.
The decoration of thermochromic ink has applications ranging from engineering devices to liquid sensors. However, when it comes to accurate computer identification the characteristic as dichroism is not fully used. Thus, we have recently proposed a manufacture method of dichroism infrared-reflective thermochromic ink. (DITI). By rubbing to heat DITI coated layer, this method enables us to finely and separately create dichroism manuscript after the handwriting is complete. Moreover, the microcapsules have cheerful compatibility. We have decorated conventional microcapsules with bola-type copolymer which allow us to fill them with Infrared (IR) reflective perssad. We consider this method promising to distinguish dichroism printing or writing on a tanglesome surface much quicker, for the IR reflective low-colour-density layer will be easily locked by an IR camera or a mobile phone camera to adjust specific characters of interest. We anticipate that this DITI ink will find use in markable temperature measurement, fluid machinery, anti-counterfeiting techniques and daily printing or writing.
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