MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.
Chloroform is a general solvent for poly(3-hexylthiophene) (P3HT) active layers in field-effect transistors. However, its low boiling point and rapid evaporation limit the time for
crystallization during the spin-coating process, and field-effect mobilities achieved for P3HT
films spin-coated from chloroform are typically on the order of 0.01 cm2/(V s). Here we
investigate a range of solvents with higher boiling points. We find that 1,2,4-trichlorobenzene
with good solubility and a high boiling point significantly improves the field-effect mobilities
up to 0.12 cm2/(V s) with on:off ratios of 106. By controlling the microstructure through the
choice of solvent while keeping the molecular weight fixed, we observe a clear correlation
between the field-effect mobility and the degree of microcrystalline order as measured by
X-ray diffraction, as well as the strength of polaronic relaxation of charge carriers in the
accumulation layer as measured by optical spectroscopy of field-induced charge.
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.
A "visible-blind" solution-processed UV photodetector is realized on the basis of colloidal ZnO nanoparticles. The devices exhibit low dark currents with a resistance >1 TOmega and high UV photocurrent efficiencies with a responsivity of 61 A/W at an average intensity of 1.06 mW/cm(2) illumination at 370 nm. The characteristic times for the rise and fall of the photocurrent are <0.1 s and about 1 s, respectively. The photocurrent of the device is associated with a light-induced desorption of oxygen from the nanoparticle surfaces, thus removing electron traps and increasing the free carrier density which in turn reduces the Schottky barrier between contacts and ZnO nanoparticles for electron injection. The devices are promising for use in large-area UV photodetector applications.
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