The percolation model fulfills the accuracy requirements for quality-control procedures when large ranges of doses are used and offers a physical explanation for the film response.

During Inflammaging, a dysregulation of the immune cell functions is generated, and these cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and ROS. This increase in pro-inflammatory molecules contributes to the chronic inflammation and oxidative damage of biomolecules, classically observed in the Inflammaging process. One of the most critical oxidative damages is generated to the host DNA. Damaged DNA is located out of the natural compartments, such as the nucleus and mitochondria, and is present in the cell’s cytoplasm. This DNA localization activates some DNA sensors, such as the cGAS/STING signaling pathway, that induce transcriptional factors involved in increasing inflammatory molecules. Some of the targets of this signaling pathway are the SASPs. SASPs are secreted pro-inflammatory molecules characteristic of the senescent cells and inducers of ROS production. It has been suggested that oxidative damage to nuclear and mitochondrial DNA generates activation of the cGAS/STING pathway, increasing ROS levels induced by SASPs. These additional ROS increase oxidative DNA damage, causing a loop during the Inflammaging. However, the relationship between the cGAS/STING pathway and the increase in ROS during Inflammaging has not been clarified. This review attempt to describe the potential connection between the cGAS/STING pathway and ROS during the Inflammaging process, based on the current literature, as a contribution to the knowledge of the molecular mechanisms that occur and contribute to the development of the considered adaptative Inflammaging process during aging.

The new concrete CONTEK®-RFH2 increases photon attenuation and reduces the size of a shielded wall. A very high percentage in iron and a suitablesieve size approximately double the density of ordinary concrete. High mass attenuation coefficient makes this concrete an extremely desirable material for use in radiation facilities as shielding material for photon beam, and for upgrading facilities designed for less energy or less workload.

ResumoEste artigo analisa como a construção de protótipos variados com materiais de baixo custo e recicláveis feitos por alunos do Ensino Médio do Colégio Estadual Rio de Areia, escola da rede pública estadual localizada no município de Saquarema-RJ, contribui para a consciência ambiental. Analisa também como o movimento maker, movimento que defende a ideia de do indivíduo fabricar, construir, reparar e alterar objetos com as próprias mãos, utilizando-se da colaboração entre grupos, desenvolve competências e habilidades favorecendo o aprendizado em diversas áreas do conhecimento. Com a manipulação dos materiais, é explorada a conexão entre a Geometria e o cotidiano do aluno, aproveitando-se do tema para apresentar sugestões de como se chegar a algumas fórmulas de áreas de figuras planas com uma linguagem simples e de forma intuitiva, sem o rigor das demonstrações matemáticas, alcançando o entendimento de todos os alunos do Ensino Médio.Palavras-chave: Geometria; Matemática; Movimento maker; Interdisciplinaridade. AbstractThis article analyzes how the construction of varied prototypes with low cost and recyclable materials made by high school students from the Rio de Areia State School, a public school located in Saquarema-RJ, contributes to environmental awareness. It also analyzes how the maker movement, a movement that defends the idea of the individual making, building, repairing and altering objects with their own hands, using collaboration between groups, develops competences and skills favoring learning in various areas of knowledge. With the manipulation of materials, the connection between Geometry and the student's daily life is explored, taking advantage of the theme to present suggestions on how to arrive at some formulas of flat picture areas with simple and intuitive language, without accuracy of mathematical demonstrations, reaching the understanding of all high school students.