No abstract

First quantitative phosphoproteome analysis of TDM-activated macrophages reveals new insights in biological processes of macrophages stimulated with the mycobacterial cord factor. Surprisingly, the bioinformatic results revealed Mincle-dependent and-independent phosphorylation, which appear to affect different biological processes. Whereas PI3K/AKT signaling, dependent on Mincle, is involved in TDM-induced cytokine regulation, Mincle-independent phosphorylation and transcriptomic changes were linked to cell cycle regulation. Collectively, the observed reprogramming of macrophages by TDM might be relevant in the mycobacteriamacrophage interaction.

This information is current as GBP1 Antigen Presentation and Expression of Enhanced Inflammation yet Impaired towards γ Macrophage Response to IFN-Mycobacterial Cord Factor Reprograms the Lang