Results suggest that GNG inhibitory control training paradigms can influence health behaviour, but perhaps only in the short-term. Future research is required to systematically examine the influence of training duration, and the longevity of the training effect. Determining these factors could provide the basis for cost-effective and efficacious health-promoting interventions.

After completing this course, the reader will be able to:1. Discuss the danger inherent in nondisclosure of complementary and alternative medicine (CAM) use due to the potential for herb-or vitamin-drug interactions with conventional treatment.2. Explain the need for greater patient-doctor communication about CAM use in oncology settings in order to maintain patient safety and wellbeing.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME Results. A total of 21 studies were located, which reported a prevalence of CAM use among patients with cancer ranging between 11% and 95%; of these patients, 20% to 77% did not disclose their CAM use. The main reasons for nondisclosure were the doctor's lack of inquiry; patient's anticipation of the doctor's disapproval, disinterest, or inability to help; and patient's perception that disclosure of CAM use is irrelevant to their conventional care. There is some evidence to suggest that patient-doctor communication about the use of CAM was associated with an enhanced patient-doctor relationship and higher patient satisfaction. ABSTRACT Conclusions. Although the use of CAM by patients with

The current paper presents a future research agenda for intolerance of uncertainty (IU), which is a transdiagnostic risk and maintaining factor for emotional disorders. In light of the accumulating interest and promising research on IU, it is timely to emphasize the theoretical and therapeutic significance of IU, as well as to highlight what remains unknown about IU across areas such as development, assessment, behavior, and relationships to emotional disorders. The present paper was designed to provide a synthesis of what is known and unknown about IU, and, in doing so, proposes broad and novel directions for future research to address the remaining uncertainties in the literature.Keywords: intolerance of uncertainty, review, emotional disorders, transdiagnostic, disorder-specific, research agenda WHAT UNCERTAINTIES REMAIN? 3 Intolerance of Uncertainty in Emotional Disorders: What Uncertainties Remain?The current paper briefly reviews what is known about intolerance of uncertainty (IU) before highlighting what remains unknown. Due to rapidly increasing interest and research focus on IU, culminating in the current special issue, a review is both timely and necessary to set a future research agenda. This paper will review IU with respect to conceptual foundations and definitional issues, development, assessment, behavioral consequences, associations to threat and risk, other cognitive vulnerability factors, emotional disorders, as well as clinical applications.Within each of these domains, what is currently known will first be briefly reviewed followed by what remains unknown. The major contribution of the current paper is the description of future research avenues to address the known unknowns. Conceptual Foundations of Intolerance of Uncertainty What is known?Models of psychopathology posit that uncertainty is a central feature in anxiety-related experience (Carleton, 2016) and the incapacity to endure unknowns appears to be a robust vulnerability factor associated with a range of psychological disorders (Grupe & Nitschke, 2013;Hong & Cheung, 2015). IU was originally defined as a broad construct that reflects "cognitive, emotional, and behavioral reactions to uncertainty in everyday life situations" (Freeston, Rhéaume, Letarte, Dugas, & Ladouceur, 1994, p. 792). Freeston and colleagues (1994) speculated that people with IU may engage in worry to increase their sense of certainty and control when faced with ambiguity. The definition of IU evolved as research on IU shifted from an initial focus on generalized anxiety disorder (GAD) to other disorders. A revised and broader definition described IU as a predisposition to negatively perceive and respond to uncertain information and situations irrespective of its probability and outcomes (Ladouceur, Blais, WHAT UNCERTAINTIES REMAIN? 4 Freeston, & Dugas, 1998;Ladouceur, Gosselin, & Dugas, 2000). IU has also been conceptualized as a cognitive filter and as the excessive tendency to perceive and interpret negative events as unacceptable (Buhr & Dugas...