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Introduction:The COVID-19 disease is a viral infection that can be complicated by different risk factors and can lead to death. Objective: To analyze the factors associated with the outcome (discharge or death) of patients with Covid-19 admitted to an intensive care unit. Methodology : Retrospective cross-sectional study with data from medical records of patients with Covid-19 admitted to the ICU of a university hospital in Cuiabá-MT, aged ≥ 20 years, of both genders, including pregnant women. Demographic, clinical, nutritional status and patient outcome variables were collected. Bivariate analysis was performed using Fisher's Exact Test and binary logistic regression using SPSS 17.0, with p<0.05 considered significant. Results: A total of 125 patients were evaluated, of which 53.6% were Gender Female and 46.3% were pregnant, with a mean age of 48.66 ± 18.33 years, most adults (71.2%) and of race/color brown (72.0%). Regarding comorbidities, 32.8% of the patients had arterial hypertension, 15.2% diabetes, 9.6% cardiovascular diseases, 5.6% other comorbidities, and 31.2% developed acute kidney injury (AKI). In the bivariate analysis, the outcome death was associated with Age of the elderly (p<0.001), hypertensive (p=0.002), presence of AKI (p=0.014) and two or more comorbidities (p=0.007), and Gestation (p=0.037). In the final multiple analysis, the outcome of death remained associated with the age of the elderly (p=0.004) and the presence of AKI (p=0.006). Conclusion:The presence of comorbidities, older age and the development of AKI were factors significantly associated with death in patients with Covid-19.