Giriş: Çalışmamızın amacı hastaneye yatan hastaların aşı durumlarını tespit edip, hastaneye yatışta aşının önemini belirlemek. Yöntem: Bir pandemi hastanesinde 3 aylık süreçte (haziran-ağustos 2021) COVID-19 tanısı alan ve yalnızca nazal ve faringeal sürüntü örneklerinin real time polimeraz zincir reaksiyonu (RT-PCR) testinde pozitif sonuç veren enfeksiyon hastalıkları ve klinik mikrobiyoloji servisinde ardışık olarak yatan 177 hasta dahil edildi. Aşılama durumu değerlendirildi. Bulgular: COVID-19 tanısı alan 177 olgu çalışmaya alınmıştır. Hastalar ülkemizde yapılan aşılama programına uygun olacak şekilde sınıflandırıldı. Hastaların 41’i (%23) aşısız, 5’i (2.8) tek doz Sinovac, 63’ü (35,6) iki doz Sinovac, 17’si (9,6) üç doz Sinovac, 14’ü (7,9) tek doz Pfizer-BioNTech, 22’si (12,4) iki doz Pfizer-BioNTech 15’i (8,5) iki doz Sinovac tek doz Pfizer-BioNTech yaptırmıştı. Katılımcıların %23,2’si aşı olmamıştı, %2,8’i tek doz sinovac aşısı olmuştu. Sonuç Etkin bir aşılama COVID-19 ile ilgili hastaneye yatışları azalttığı görüldü. Covid-19 salgını dünya çapında milyonlarca insanın yaşamını tehdit eden ve binlerce insanın ölümüne sebep olması göz önüne alındığında aşılamanın önemli olduğunu bir kez daha açık bir şekilde ortaya koymaktadır. Çalışmamızda tam aşılılarda ölüm oranı oldukça düşük saptandı. Ülkemizde toplum bağışıklığın sağlanması, sürdürülebilir sağlık hedeflerinin belirlenmesi için her bireyin aşılama ile ilgili üzerine düşen rolü yerine getirmesi gerektiği düşünülmektedir.

Aim: Healthcare-associated infections are a major source of concern in all areas of hospitals, particularly in intensive care units. The goal of our study was to look at the current situation and evaluate the measures that can be taken based on the data obtained by examining the rates and factors of healthcare-associated infections in the general intensive care units of our hospital over a one-year period. Materials and Methods: Between January 2020 and December 2020, 665 patients who were followed up and treated in the general intensive care unit of Meram State Hospital were followed up in terms of healthcare-associated infections, and their outcomes were evaluated. Results: 5354 hospitalization days of 665 patients who were followed up in the general intensive care units for a year were evaluated, and it was determined that 53 of the patients developed healthcare-associated infections. Twenty-two (41.5%) of patients with healthcare-associated infections were female, while 31 (58.5%) were male. It was discovered that the patients' mean age was 71,7±14 (19-94). The infection rate was calculated to be 5.86 and the density to be 7.28. Furthermore, the rates of invasive device-associated nosocomial infection are as follows: 1.02 for central line-associated bloodstream infections, 0.56 for catheter-associated urinary tract infections, and 0 for ventilator-associated pneumonia. Conclusion: Healthcare-associated infections are a significant cause of mortality and morbidity in intensive care units. Due to the improvement in medical care and the increase in life expectancy in parallel with this, effective surveillance practices are of critical importance.

Objective: In this study serum tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF- beta), interleukin-10 (IL–10) and alanine transferase (ALT) levels were measured in naive chronic hepatitis C patients and healthy control group. The relationship between the values and the histological activity of the liver was evaluated to make predictions about liver histology without the need for biopsy. Methods: A total of 86 individuals including 43 patients and 43 controls participated in the study. Serum AST, ALT, TNF-alpha, TGF- beta and IL–10 values were analyzed in patient and control groups. The correlation between liver fibrosis degree (stage) and histological activity index (HAI) scores and the IL–10, TNF-alpha, IL-10, TGF-BETA values of the case and control group was evaluated. Results: A very strong correlation was found between HAI and TNF-alpha (rho=0965). A significant relation was found between HAI and TGF-beta (rho=0.446) and statistical correlation was not found between HAI and IL-10. A significant relation was found between HAI and serum ALT values in the patient group. Conclusion: Liver biopsy is an invasive procedure with complications which may have severe results. There is a need for biochemical or radiological markers which extrapolate to liver biopsy. In our study, measurement of serum cytokine and ALT values was observed as a noninvasive method which can help to meet this need.