Experimental studies reveal that genome architecture splits into natural domains suggesting a well-structured genomic architecture, where, for each species, genome populations are integrated by individual mutational variants. Herein, we show that the architecture of population genomes from the same or closed related species can be quantitatively represented in terms of the direct sum of homocyclic abelian groups defined on the genetic code, where populations from the same species lead to the same canonical decomposition into p -groups.  This finding unveils a new ground for the application of the abelian group theory to genomics and epigenomics, opening new horizons for the study of the biological processes (at genomic scale) and provides new lens for genomic medicine.