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TAVI is becoming a new therapeutic method for elderly patients with severe co-morbidities and severe symptomatic aortic stenosis. Complications of TAVI are not trivial and their management by catheter techniques is challenging. In consequence the selection of patients and of suitably experienced hospitals is crucial for the further development of this promising new technique.

Abstract-Software modernization has been extensively researched, primarily focusing on observing the associated phenomena, and providing technical solutions to facilitate the modernization process. Software modernization is claimed to be successful when the modernization is completed using those technical solutions. Very limited research, if any, is reported with an aim at documenting the post-modernization impacts, i.e., whether any of the pre-modernization business goals are in fact achieved after modernization. In this research, we attempt to address this relative absence of empirical study through five retrospective software modernization case studies. We use an explanatory case study approach to document the pre-modernization business goals, and to decide whether those goals have been achieved. The intended benefits for each of the five cases we considered were all (partially) met, and in most cases fully. Moreover, many cases exhibited a number of unintended benefits, and some reported detrimental effects of modernization.

An extensive hemorrhage in the pharynx appeared in association with dipyridamole administration to a diabetic patient. The hemorrhage caused dysphagia and subsided when the drug was discontinued. Coagulation tests were normal except for a decreased platelet aggregation. Platelet factor 3 and the aggregation tests with adenosine diphosphate and epinephrine were abnormal during the hemorrhagic event and returned to normal after discontinuation of the drug.