Organizational culture is one of the most important factors that provide sustainable success for an organization, which consists of performance and effectiveness of a company, the morale of its employees; and its ability to attract, motivate, and retain talented people. Organizational culture takes time to develop and change, as it is a tied system of artifacts, values, and underlying assumptions that's why it is important to examine behaviors that have a positive or negative effect on the organizational culture. This study empirically examines the relation between organizational citizenship behavior, organizational culture and organizational deviance. The proposed research model and associated hypotheses were tested based on data collected from 352 employees in the banking industry. The findings revealed that organizational behavior has a mediator role on the relationship between organizational culture and organizational deviance. The study also provides new insights to managers, leaders and policymakers about the importance of building a strong organizational culture through organizational citizenship behavior.