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Background: As HIV/AIDS has emerged to be the first modern pandemic with ever increasing prevalence globally, the present study was undertaken to study the renal profile in patients living with HIV/AIDS, not started on ART. Materials and methods: This was a hospital based observational study where 277 cases were studied in details with the aims and objectives of studying the renal manifestations in ART naïve patients with HIV/AIDS and its relationship with CD4 counts. A detailed history, clinical examination and relevant investigations were done in patients above 15 yrs of age who were not on ART. Results: Out of 277 seropositives, 40 had proteinuria (14.44%) on urine examination. The mean serum creatinine of the total study population was found to be 0.92±0.83 mg/dl while 14 cases (5%) had serum creatinine more than 1.5mg/dl. A decrease in eGFR (<60ml/min/1.73m 2) was seen in 28 (10.1%) cases. Out of 178 cases with CD4 count more than 200cells/mm 3 , renal dysfunction was found in 12 cases (6.7%), whereas the cases with CD4 count less than or equal to 200cells/mm 3 , 19 out of 99 cases (19.2%) had renal dysfunction which is statistically significant. Conclusion: In the present study, which included ART naive patients with HIV/AIDS, predominant renal involvement was in the form of proteinuria followed by raised serum creatinine levels and reduced eGFR. A negative correlation was found between renal dysfunction and CD4 counts.

Background: Various risk factors for development of hypertension, both modifiable and non modifiable ,have been identified to aid in its prevention and management. In recent years, various studies have shown serum uric acid (UA) levels to be an independent predictor for developing hypertension. This study determined the uric acid level in hypertensive patients and established a relation between hypertension and uric acid level. Materials and methods: It was a case control study done from 1 st March 2018 to 31 st August 2018,which included a total of 80 newly diagnosed hypertensive cases and 80 normotensive controls matched for age and sex admitted in the Department of Medicine GMCH. The cases were classified into the various stages of hypertension as per the JNC-7 classification criteria.One way ANOVA analysis was performed to compare the differences in mean serum uric acid levels in the various categories. Results: The mean serum uric acid level among the controls was 5.09±1.33 mg/ dl while among the cases was 5.72±1.35 mg/dl. Among the cases, mean serum uric acid in stage 1 and stage 2 HTN were 5.15±0.97 and 6.35±1.45 mg/dl respectively. There was statistically significant differences among the 3 groups, i.e between stage 1 and stage 2 HTN, between control group and stage 1 HTN and between control group and stage 2 HTN, with a p value <.05. Conclusion: There was statistically significant differences between mean serum uric acid levels of newly diagnosed hypertensive cases and age and sex matched normotensive healthy controls and it tends to rise with the severity of hypertension.