Background & Objectives: Ventilator associated pneumonia (VAP) is an important form of hospital acquired pneumonia (HAP), specifically developing in a mechanically

Lipoprotein (a) and other lipid sub-fractions are known to be associated in atherosclerosis of the carotid vessels and ischemic stroke. This study was conducted to compare the specificity of variables like lipoprotein (a), HDL and LDL as independent risk factor in determining the severity and outcome of ischemic stroke.METHODS: The data for this study was collected from 50 patients of ischemic stroke who presented to KIMS hospital from June 2012 to 2013. All of who underwent clinical assessment by NIHSS score with relevant investigations, including CT scan brain, lipoprotein (a) and lipid profile.RESULTS: Male patients had higher incidence than females. Female population had higher BMI. Stroke scoring was done using NIHSS scoring;severe cases of stroke remain equal in both the sexes. The conventional risk factors were studied and were associated with severity of stroke but statistically not significant. Various lipid subfractions were studied with respect to severity of stroke and it was found that TC had p value=0.146, HDL-C p value=0.686, LDL-C p value =0.296, VLDL-C p=0.54, TG p=0.721 and Lp (a) p<0.001.Patient with LDL-C>150mg/dl were 2.79 times more likely to have NIHSS score>15 and patients with HDL-C<40mg/dl were 2.23 times more likely to have NIHSS score >15. Low HDL-C was the only lipid abnormality seen in patients with no conventional risk factors. CONCLUSION:Ischemic stroke is associated with lipid abnormalities. Lp (a) which is genetically determined factor and HDL-C were found to be independent risk factors for predicting the outcome of ischemic stroke. Conventional risk factors were found to be less reliable.