Prediabetes in the form of impaired glucose tolerance (IGT) is common among patients with acute coronary syndrome (ACS). IGT in patients admitted for ACS is associated with increased mortality. We aimed to determine the prevalence of prediabetes in the form of IGT among ACS patients who were known to be neither diabetic nor prediabetic and referred to early coronary angiography. The study included 284 participants. We divided into 2 groups: patients group and control group. The patients group were include 138 patients admitted in AL-Hussein teaching hospital with acute coronary syndrome in the form of ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). 98 patients with NSTEMI and 40 patients with STEMI. The control group were 146 participants in the form of medical staff and patients visiting the hospital with conditions other than the ischemic coronary artery disease. All participants were neither diabetic nor prediabetic. 2 hour post prandial blood sugar, blood sugar at 3 days and blood sugar after 6 weeks were done. 22% of the patients group and 6% of the control group were found to have IGT at 2 hour postprandial with highly statistically significant value (P value < 0.0001). 16.6% of the patients group and 7.5% of the control group were found to have IGT at 3 days after the admission with highly statistically significant value (P value < 0.001). 11% of the patients group and 2% of the control group were found to have IGT after 6 weeks of the presentation with also significant statistical value (P value < 0.005). IGT was found in 62% of the female and 38% of the male in patients group. 42% of NSTEMI and 28% of STEMI patients were ended with early percutaneous coronary angiography. There were 11 patient with IGT in the patients group died during the first week of presentation in comparison to 2 patients with normal sugar died during the same period with highly statistically significant value (P value < 0.0001). IGT is common in patients admitted with ACS. IGT is associated with higher mortality among those patients with previously unreported as diabetes mellitus and should be screened for.
To study the utilization pattern of anti-diabetic drugs in type 2 diabetic patients and to evaluate the association of diabetes with demographic details and it's metabolic control. The study was carried out on 100 type 2 diabetic patients who visited AL-Nasiriya center for diabetes and endocrinology. Demographic details and complete prescriptions drugs, FBS (fasting blood sugar), HbA1c and BMI (body mass index) were recorded. A total of 100 type 2 diabetic patients, 27(27%) were males and 73(73%) were females. The greatest number of patients, 43%, were in the age group of 51-60 years. Obesity (BMI ≥ 30) were found in 51% of patients especially females 45(61.3%). Poor glycemic control (HbA1c ≥ 9) were found in 65% of the patients. Oral anti-diabetic drugs were prescribed in 53%, 16(60%) were males and 37 (50.6%) were females. Biguanide (metformin) alone, 22%, was the most common anti-diabetic drugs prescribed. Biguanides (metformin) and sulfonylurea combination, 19%, was the commonest anti-diabetic drugs combination. Insulin preparations alone were used in 23% of the patients and Novomix was the commonest type (10%). We concluded that oral anti-diabetic drugs were the most common prescribing drugs. Metformin was the commonest prescribing anti-diabetic drugs. Metformin and sulfonylurea being the most frequent combination prescribed. There were increasing in the use on insulin preparations in the treatment of type 2 diabetic patients. In achieving optimal glycemic control, the efficacy of anti-diabetic drugs was only 10%, planning of more intensification anti-diabetic treatment is necessary.
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