Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.

Abstract. A new coronavirus infection, like other infections of viral etiology, is not an indication for the use of antibiotics. The cause of lung damage in COVID-19 is immune mechanisms, in which macrophages are activated and a "cytokine storm" develops, which is not affected by antibiotics. Antibacterial therapy is prescribed only if there are convincing signs of bacterial infection adherence. Therefore, a competent and reasonable approach to prescribing antibacterial drugs during a pandemic new coronavirus infection is necessary. The aim of the study was to conduct a pharmacoeconomic analysis of COVID-19 antibiotic therapy and to identify cases of irrational prescribing of antibiotics. Case histories of 334 patients treated in a reassigned hospital infectious disease unit in October 2021 with a diagnosis of Covid-19 new coronavirus infection were analyzed. The study found that antibiotic therapy was prescribed in 52.5% of patients aged 60 years or older and 38.5% of those younger than 60 years. A single antibacterial was the most frequently prescribed antibiotic 66.4% in the elderly and 78% in the young. Levofloxacin was most frequently prescribed as a starting antibiotic (32.7% of all AB prescriptions in the elderly and 54% in the young). Ceftriaxone (17.8%), Cefotaxime (15.9%), and Cefotaxime + Sulbactam (13.1%) were also commonly prescribed in those over 60 years of age. The effectiveness of antibacterial agents in the treatment of NKI was calculated using a cost-effectiveness pharmacoeconomic analysis using the criteria of therapy duration, length of hospital stay, and prescription of a second antibiotic. The best cost-effectiveness ratio was observed for prescribing ciprofloxacin (5.5), ceftriaxone (13.2), and cefotaxime (32.1) to the elderly. Irrational prescribing of antibiotics was noted in 10.8% of all antibiotic prescriptions. Of all irrational prescriptions, levofloxacin accounted for the largest number (64.7%).

Abstract. The article presents the results of the effectiveness of preventive antiarrhythmic monotherapy with sotahexal and cordarone based on heart rate variability and examination of patients at intervals of every 3 months for one year. The relevance of studying heart rate variability indicators is beyond doubt. The simplicity and non-invasiveness of this procedure dictates its increasing use. As a result of the study, the mechanism of occurrence of paroxysms of atrial fibrillation was shown both in patients with the existing paroxysmal form of atrial fibrillation, and in comparison, groups, where the debuts of this disease were recorded as a result of the study. It is known that with age there is an increase in diseases of the cardiovascular system, including atrial fibrillation. Elderly patients make up the bulk. Therefore, properly selected antiarrhythmic therapy based on heart rate variability indicators can help reduce morbidity in this group of patients. When studying the effectiveness of antiarrhythmic therapy on the example of representatives of the III class of antiarrhythmic drugs sotahexal and cordarone, it was found that the effectiveness of monotherapy with sotahexal and cordarone by the end of 1 year of the study was 74 and 71%, respectively. Indicators of heart rate variability in patients receiving sotahexal after 1 year did not significantly differ from each other, and at the initial stage of treatment, indicators characterizing the tone of the parasympathetic nervous system prevailed over the same indicators of patients receiving cordarone, over the tone differed from the initial ones in the downward direction. In patients receiving cordarone, a year later, there was a shift in the vegetative balance towards sympathicotonia compared with baseline indicators.

Abstract. The study shows the values of heart rate variability in patients with paroxysmal atrial fibrillation treated with allapinin monotherapy and a combination of allapinin with metoprolol, allapinin with sotahexal and allapinin with diltiazem with preventive antiarrhythmic therapy. Analysis of heart rate variability allows you to determine the state of the autonomic nervous system. A high probability of an unfavorable outcome of diseases of the cardiovascular system is observed with the predominance of the tone of the sympathetic nervous system and a decrease in the tone of the parasympathetic nervous system. A decrease in heart rate variability and a predominance of sympathetic nervous system tone are predictors of the occurrence of another paroxysm in patients with paroxysmal atrial fibrillation. Indicators of heart rate variability are of great importance in the selection of antiarrhythmic therapy. The initial predominance of the tone of the parasympathetic nervous system in comparison with healthy ones and the absence of negative dynamics after 1 year was recorded in patients with paroxysmal atrial fibrillation with allapinin monotherapy. Patients treated with a combination of allapinin and metoprolol had a predominance of the tone of the parasympathetic nervous system initially compared with the healthy group and a transition to sympathicotonia after 1 year compared with healthy, control and their own baseline values. Patients receiving allapinin and sotahexal had no significant differences either at the beginning of the study or after 1 year. Predominance of sympathetic nervous system tone was registered in patients treated with allapinin and diltiazem by the end of 1 year of the study in comparison with a group of healthy.

To improve the quality of drug care for patients with arterial hypertension, using a sociological survey, we determined prognostic parameters that determine the risks of developing the disease, which included: hereditary burden, duration of the disease, blood pressure indicators, the presence of concomitant diseases, the frequency of blood pressure measurement, lifestyle, adherence to treatment, quality of life indicators, assessment of the significance of factors in the choice of antihypertensive drugs. The results of the analysis of patient survey data showed that most patients do not underestimate the significance of these parameters, do not have enough knowledge necessary for effective treatment. As an organizational and functional form of improving the professional interaction of medical and pharmaceutical specialists in order to meet the information needs and improve the quality of life of patients, the creation of a medical and pharmaceutical school was recommended. The main purpose of the functioning of the Medical and Pharmaceutical School is to increase the educational level of patients.