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ObjectiveThis study aimed to assess the association of clinical factors with P2Y12-dependent platelet inhibition as monitored by the ratio of ADP- to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively.BackgroundControversial findings to identify and overcome high platelet reactivity (HPR) after coronary stent-implantation and to improve clinical outcome by tailored anti-platelet therapy exist. Monitoring anti-platelet therapy ex vivo underlies several confounding parameters causing that ex vivo platelet aggregation might not reflect in vivo platelet inhibition.MethodsIn a single centre observational study, multiple electrode aggregometry was performed in whole blood of patients after recent coronary stent-implantation. Relative ADP-induced aggregation (r-ADP-agg) was defined as the ratio of ADP- to TRAP- induced aggregation reflecting the individual degree of P2Y12-mediated platelet reactivity.ResultsPlatelet aggregation was assessed in 359 patients. Means (± SD) of TRAP-, ADP-induced aggregation and r-ADP-agg were 794 ± 239 AU*min, 297 ± 153 AU*min and 37 ± 14%, respectively. While ADP- and TRAP-induced platelet aggregation correlated significantly with platelet count (ADP: r = 0.302; p<0.001; TRAP: r = 0.509 p<0.001), r-ADP-agg values did not (r = -0.003; p = 0.960). These findings were unaltered in multivariate analyses adjusting for a range of factors potentially influencing platelet aggregation. The presence of an acute coronary syndrome and body weight were found to correlate with both ADP-induced platelet aggregation and r-ADP-agg.ConclusionThe ratio of ADP- to TRAP-induced platelet aggregation quantifies P2Y12-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation. Furthermore, r-ADP-agg was associated with the presence of an acute coronary syndrome and body weight as well as ADP-induced aggregation. Thus, the r-ADP-agg is a more valid reflecting platelet aggregation and potentially prognosis after coronary stent-implantation in P2Y12-mediated HPR than conventional ADP-induced platelet aggregation.

Freie Vortr/~ge Zusammen/assung. Vergleichende morphologisehe Untersuchungen an der Muskulatur des Canalis egestorius yon 12 magengesunden Organspendern und an 28 ResektionsprKparaten yon Ulcera ventrieuli lassen eine Pyloroantralerkrankung als patho-physiologische Voraussetzung des Ulcusleidens, bei dem das Ulcus selbst lediglich ein Symptom darstellt, als wahrseheinlich erscheinen. Im Vordergrund der yon der Ulcuslokalisation unabh~ngigen Muskelver~nderungen im Antrum und Pylorus stehen: Wandverdicktmg infolge Muskelhyperplasie, WandSdem, Bindegewebsvermehrung, Degenerationsprozesse an Muskelzellen und ihren Kernen, Muskelgewebseosinophilie und Zellinfiltrate.

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