To the foundation of a principally new short-term forecasting method there has been laid down a theory of surrounding us world’s creation and of physical vacuum as a result of interaction of byuons-discrete objects. The definition of the byuon contains the cosmological vector-potential Ag- a novel fundamental vector constant. This theory predicts a new anisotropic interaction of nature objects with the physical vacuum. A pe- culiar “tap” to gain new energy (giving rise to an earthquake) are elementary particles because their masses are proportional to the modulus of some summary potential A∑ that contains po- tentials of all known fields. The value of A∑ cannot be larger than the modulus of Ag. In ac- cordance with the experimental results a new force associated with A ejects substance from the area of the weakened A along a conical formation with the opening of 100° ± 10° and the axis directed along the vector A∑ . This vector has the following coordinates in the second equatorial coordinate system: right ascension α≈ 293°± 10°, declination δ≈36° ± 10°. The 100% probability of an earthquake (earthquakes of 6 points strong and more by the Richter scale) arises when in the process of the earth rotation the zenith vector of a seismically dangerous region and/or the vectorial potential of Earth’s magnetic fields are in a certain way oriented relative to the vector Ag. In the work, basic models and standard mechanisms of earth- quakes are briefly considered, results of proc- essing of information on the earthquakes in the context of global spatial anisotropy caused by the existence of the vector Ag, are presented, and an analysis of them is given