Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Despite the fact that various therapeutic compounds have shown potential prevention or treatment, no specific medicine has been developed for the COVID-19 pandemic. Natural products have recently been suggested as a possible treatment option for COVID-19 prevention and treatment. This study focused on the potential of Coriander sativum L. (CSL) against COVID-19 based on network pharmacology approach. Interested candidates of CSL were identified by searching accessible databases for protein–protein interactions with the COVID-19. An additional GO and KEGG pathway analysis was carried out in order to identify the related mechanism of action. In the end, 51 targets were obtained through network pharmacology analysis with EGFR, AR, JAK2, PARP1, and CTSB become the core target. CSL may have favorable effects on COVID-19 through a number of important pathways, according to GO and KEGG pathway analyses. These findings suggest that CSL may prevent and inhibit the several processes related to COVID-19.

With the uncertainty of COVID-19 disease around the world, the discovery and development of novel treatments for COVID-19 becoming an emerging trend. Network pharmacology has been used for determining the potential targets from several diseases. This research mainly focused on the potential of Allium schoenoprasum against COVID-19 based on a network pharmacology approach. The methods consist of target identification of the compounds, target identification related to COVID-19 disease, compound-target interaction network, protein-protein interaction network and gene ontology and pathway enrichment analysis. Fifthy three main targets obtained from the compound-COVID-19 were identified as main targets from the compounds with MMP9, MPO, TLR4, MMP2, CCNB1, AURKB, PLK1, TOP2A, ALOX5, and CD38 becoming the top 10 core targets. Phenolic compounds in Allium schoenoprasum may act as anti-COVID-19 through several inflammatory and immune response pathways. Based on these results, it seems that phenolic compounds in Allium schoenoprasum might act as anti-COVID-19 via network pharmacology approaches.