Objective: To find out the effect of a ketogenic Diet (KD) on the biochemical and anthropometric parameters. Methodology: This experimental study was conducted at the physiology laboratory of Khyber Medical University from January 2022 to June 2022. Using non probability convenience sampling, forty-six subjects were recruited for the study following the inclusion and exclusion criteria. Non-probability convenience sampling method was used. Subjects were given KD for twenty-eight days. Blood samples were collected for biochemical parameters along with anthropometric measurements on Day 1 and Day 29 of the study. Paired sample t test was used for pre- and post-trial comparison and ANOVA was used for comparison at day 0, and 29th day. Results: All the physical and chemical parameters like weight, body mass index, MUAC, biceps, Triceps, sub-scapular, waist circumference, hip circumference, fasting blood sugar, ketone level, glucose ketone index, body fat and water mass muscle mass reduced from 1st day to 29th day statically. Two parameters (height and visceral mass) show an insignificant change in results from day 1st to day 29th.

Objective: To determine the effect of a ketogenic diet (KD) on the levels of insulin and thyroid hormone in healthy adult individuals. Methodology: This single-arm comparative experimental study was conducted at the Clinical trial room and Physiology laboratory, Khyber medial university, Peshawar. A total of 46 individuals were selected falling under the inclusion criteria. Ketogenic diet was given to the participants for four weeks. Blood was obtained from subjects on day 1, and after 29 days. Paired sample t test was used for pre- and post-trial comparison and ANOVA was used for comparison at day 0, and 29th day. Results: Mean age was 29.8±5.28 years. The mean value of thyroid stimulating hormone (0.005), T3 (<0.001) and insulin (0.003) statistically decrease from day 1 to day 29. But mean value of T4 increased from day 1 (6.26±0.8301) to day 29 (7.70±0.931). However, there was no significant difference for thyroid releasing hormones (TRH) on day 1 and day 29 (0.139). Conclusion: The KD statistically reduced the level of TSH, T3, TRH and Insulin while T4 level increases.  The clinicians should take into consideration patients with thyroid disorders or diabetes while prescribing KD.