These vitamins were active in performing their anti-oxidant function, as indicated by significant depression in their levels during the acute (proteinuric) phase, followed by partial recovery during remission. It may be concluded that steroid responsive nephrotic syndrome in children is associated with oxidative stress.

Aims: Coronary artery disease (CAD) is an inflammatory disorder. Recently low vitamin D and high lipoprotein ‘a’ (Lp‘a’) have been linked in causation of coronary artery disease. This study was conducted to see the the combined effect of these two modifiable risk factors i.e. low vitamin D and high Lp‘a’ in etiology of CAD. Methods: It was a cross sectional study. Triple vessel disease patients (n=31) admitted for bypass surgery were taken as cases and age and gender matched healthy persons were taken as controls (n=30). Serum vitamin D estimation was done by competitive ELISA method. Serum Lp‘a’ estimation was done by immunoturbidimetric assay. Results: when subjects were compared for dual risk factor (Vitamin D deficiency and Hyperlipoproteinemia‘a’), it was observed that the odds of having disease were very high (OR=30.00; p=0.0004) than the single risk factor (OR for Hypovitaminosis D = 3.33; p=0.03 and OR for Hyperlipoproteinemia ‘a’ = 5.00; p=0.004). The Pearson’s correlation coefficient for the relationship between serum Vitamin D and Lipoprotein ‘a’ shows no correlation (r = ̶ 0.1019). Conclusion: Risk of having CAD increases many folds when subject has vitamin D deficiecy as well as high Lp‘a’.

Background: Subclinical Hypothyroidism (SCH), according to the endocrine web is defined as an elevationin in Thyroid Stimulating Hormone (TSH) level (4.6-10 m I U/L) with thyroid hormone levels in the normal range. Magnesium (Mg2+) is an essential macro-mineral in human body, which acts as a cofactor for more than 300 enzymes. Zinc (Zn+2) is required for proper functioning of 5-deiodinase & it is a cofactor for Thyrotropin -Releasing Hormone (TRH). Transcription factorsbind to thyroid hormones which are fundamental for modulation expression of gene, also contain Zn2+ bound to cysteine residues. Aim and objectives: This study aim to estimate the levels of serum magnesium and zinc in patients of SCH. Material and methods: The serum TSH, Total Triiodothyronine (T3)& Thyroxine (T4) levels were estimated by ELISA method to identify the cases of SCH. The concentration of serum magnesium was analyzed using semiautomated analyzerbyspectrophotometry. Serum zinc was analyzed by fully automated analyzer (Vitros 5600) in patients of SCH. Results:In SCH, both T3, T4 were within the normal range and TSH in the range of 4.6-10 m I U/L, there was a statistically significant (p<0.001) decrease in serum zinc levels and not significantly decrease in serum magnesium levels in subclinical hypothyroidism patients.