Clinical RelevanceApplication of metalloproteinase synthetic inhibitors such as 2% chlorhexidine does not compromise immediate dentin bond strength of self-adhesive resin cements. The application of 24% ethylenediamine tetra-acetic acid (EDTA) gel increases dentin bond strength when self-adhesive resin cements containing methacrylated phosphoric acid ester monomers are used. Since EDTA is also considered a synthetic matrix metalloproteinase inhibitor, 24% EDTA gel might be a simple alternative to be used in conjunction with selfadhesive resin cements to improve their clinical performance. SUMMARYThis study evaluated the effect of dentin pretreatment with 2% chlorhexidine (CHX) or 24% ethylenediamine tetra-acetic acid gel (EDTA) on the dentin microtensile bond strength (lTBS) of resin cements. Composite blocks were luted to superficial noncarious human dentin (n=10) using two resin cements (RelyX ARC [ARC] and RelyX U100 [U100]) and three dentin pretreatments (without