5-Hydroxymethylfurfural (HMF) is a bio-based platform
chemical
that can be used as a building block to produce several compounds
with diverse applications. Even though HMF synthesis holds promise
for a greener future, the current state of technology and the high
production cost limit its competitiveness on an industrial scale.
In this prospect, we have developed a multigram-scale procedure for
HMF by reacting d-fructose with Purolite CT275DRan
acidic resinin a dimethyl carbonate (DMC)/tetraethyl ammonium
bromide (TEAB) biphasic system. Reactions performed in an autoclave
for 2 h at 110 °C using up to 40 gram of d-fructose
resulted in an overall HMF yield of 70%. HMF was purified by a custom-made
procedure leading to ca 50% of the pure crystalline product; meanwhile,
the residual HMF-rich oil was directly reduced to bis(hydroxymethyl)furan
(BHMF). Green metrics and the Ecoscale algorithm were used to evaluate
the sustainability of the herein-proposed procedure in comparison
with previously reported works.
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