A pandemia COVID‑19 foi declarada uma emergência de saúde mundial. Estima‑se que poderá originar um elevado nível de sofrimento, prevendo‑se que o período de crise origine variados desafios na esfera da saúde mental, tanto na população geral como nas pessoas com perturbação mental prévia. O sofrimento psicológico e angústia generalizada devido ao impacto imediato do vírus na saúde, mas também a necessidade de implementar medidas de quarentena, de isolamento físico associado à perda nas atividades educativas e laborais, adivinham o medo da doença, o receio da morte e incerteza quanto ao futuro. Por outro lado, estima‑se que a pandemia COVID‑19 poderá afetar de modo desproporcional populações mais vulneráveis, nomeadamente os profissionais de saúde e aqueles com antecedentes prévios de perturbação mental.  Pela ameaça de problemas da saúde mental que a população em geral pode enfrentar e a possível agudização da condição de base nos doentes com perturbação mental prévia éimportante uma avaliação dos vários problemas emergentes. Com efeito, os serviços de saúde mental necessitam de uma adaptação estrutural de modo a lidar com o risco acrescido das morbidades psiquiátricas, desenvolvendo e implementando programas de rastreio e intervenção precoce, que visem não apenas os efeitos agudos, mas também os efeitos a longo prazo ou crónicos desta pandemia.  A elaboração deste artigo de revisão tem por objetivo reunir, de forma rigorosa, a informação dispersa em variadas fontes científicas atualmente existentes sobre o impacto da infeção por COVID‑19 na saúde mental, assim como a experiência clínica no terreno. Deste modo, os autores realizaram uma revisão da literatura, pela pesquisa através da PubMed e Medscape usando as palavras‑chave “Pandemic”, “COVID‑19”, “Mental Health”, “Mental Disorder”.  O artigo propõe‑se a desenvolver de forma concisa e sumária algumas das problemáticas particulares inerentes à pandemia COVID‑19 e saúde mental, propondo ainda algumas estratégias e intervenções para fazer face à situação de crise vivida. Considera‑se, no entanto, a necessidade futura da contínua realização de estudos e avaliação da experiência prática, de modo a reorientar as políticas e medidas de intervenção na saúde mental.

This article discusses the notions of "democracy" and "coup d"état", from a reflection on the epistemicand consequently academicdependence experienced by the Social Sciences in Latin America, particularly by Political Science. This will be done starting from an approach based on critical theory, understood in an ecumenical waywhich implies the use of analytical contributions from Marxist, Dependentist, Postcolonial, Poststructuralist, Decolonial and other theoretical sources. More specifically, we will focus on the notions of coloniality of knowledge and epistemic dependence. From these, we will try to understand the limitations of the Latin American Social Sciences and particularly of Political Science, its space and its analytical poweras opposed to a system of knowledge based on a geopolitical location that presents itself as "universal".

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TGCTs represent a model of curable disease afflicting especially young men. Defining tumor biological characteristics is crucial to increase current knowledge and tailor the best clinical management. Ki67, a potential prognostic marker, still exhibits heterogenous associations with patient outcomes, thus bringing the need of corroboration with larger cohorts in clinical practice. LSD1, an epigenetic enzyme, represents a future target for epigenetic drugs that may lower treatment-associated morbidity. This study aimed to assess Ki67/LSD1 immunoexpression across all TGCT histological subtypes and correlate it with clinicopathological features. Results were compared with an in silico analysis of the TCGA database. Immunohistochemistry for Ki67 and LSD1 was carried out in a cohort of 157 TGCT tumor samples and assessed using a digital pathology algorithm. LSD1 protein expression was explored in TGCT cell lines, including ATRA-differentiated clones. There was a significant positive correlation between Ki67 and LSD1 H-scores (rs = 0.182, p = 0.037). Ki67 positivity percentage and H-score were significantly higher in non-seminomas (p = 0.0316 and 0.0113, respectively). Expression was not significantly different according to clinicopathological features, including stage, IGCCCG prognosis-based system, or relapse/progression-free survival, which was corroborated by in silico analysis. Our study, making use of digital image analysis, does not confirm the utility of these biomarkers in a daily practice cohort. Although not affecting patient outcome in our cohort, LSD1 is expressed overall in TGCTs, suggesting sensitivity to LSD1 inhibitors.

Background: to understand if patients seen at Centro Hospitalar Psiquiátrico de Lisboa (CHPL) live in geographical clusters or randomly throughout the city, as well as determine their access to the psychiatric hospital and primary care facilities (PCF). Methods: spatial autocorrelation statistics were performed (queen criterion of contiguity), regarding all patients observed at CHPL in 2017 (at the census subsection level), and considering not only their overall number but also main diagnosis, and admission to the psychiatric ward-voluntary or compulsory. Distance to the hospital and to the closest PCF was measured (for each patient and the variables cited above), and the mean values were compared. Finally, the total number of patients around each PCF was counted, considering specified radius sizes of 656 and 1000 m. Results: All 5161 patients (509 psychiatric admissions) were geolocated, and statistical significance regarding patient clustering was found for the total number (p-0.0001) and specific group of disorders, namely Schizophrenia and related disorders (p-0.007) and depressive disorders (p-0.0002). Patients who were admitted in a psychiatric ward live farther away from the hospital (p-0.002), with the compulsory admissions (versus voluntary ones) living even farther (p-0.004). Furthermore, defining a radius of 1000 m for each PCF allowed the identification of two PCF with more than 1000 patients, and two others with more than 800. Conclusions: as patients seem to live in geographical clusters (and considering PCFs with the highest number of them), possible locations for the development of programs regarding mental health treatment and prevention can now be identified.