Polycystic ovary syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that contains several theories about its etiology, including insulin resistance (IR) as a possible triggering factor for PCOS. Given this thesis, the implication of insulin resistance in the clinical management of PCOS is questioned. This research aimed to review the characteristics and pathophysiology of polycystic ovary syndrome, having as main focus women with PCOS who have insulin resistance and what this would imply in the etiology and its clinical management. An integrative bibliographic review of scientific studies, published between 2012-2022, was carried out on the relationship between PCOS and metabolic disorders linked to IR that interferes with clinical management. The analysis of the articles revealed that IR interferes with the pathophysiology of PCOS and may be related to its origin. It was also found that the use of oral contraceptives can affect the IR in individuals with PCOS and that the first choice in clinical management is to change the lifestyle of this population. It is concluded that the first-line treatment in this population is a lifestyle change, however, studies on the correlation of PCOS and IR regarding its etiology and the use of oral contraceptives in patients with PCOS associated with IR are still lacking.

Introduction: During pregnancy, many physiological changes occur in women secondary to the metabolic demands of the fetus, placenta, and uterus and the increasing levels of sex hormones. The hormonal peak is characterized by the increase in estrogen, progesterone, and androgen which have receptors in various tissues, with the ability to modify them. The purpose of the research is to analyze the emergence/progression of refractive errors during pregnancy, describe the pathophysiology, identify if there is an improvement in the postpartum period, if there is a need for treatment, and verify the relationship between the mode of delivery and the RE. Material and methods: A bibliographic review was carried out with research restrictions from 2000 to 2022, being selected thirty-one studies. It also had a theoretical basis in books and reports. Results and discussions: Since the gestational period is related to physiological, pathological changes or changes in certain conditions, we have to take into account that the ocular tissues can change. The presence of sex hormone receptors in eye tissues been observed, which are affected during pregnancy, causing eye disorders to be exacerbated or ameliorated. Conclusion: Most authors conclude that RE can occur during pregnancy, however, many have inconclusive results. RE are physiological changes during this period, not requiring treatment, as they tend to regress after delivery. Changes in the RE and the mode of delivery should not be taken into account. More research is needed on the subject, as many articles contradict each other, despite the changes in the cornea being confirmed.

The quantity of human skin in Brazilian's skin center is insufficient to attend less than 1% of treatments of burning. Therefore, new studies were appointed to use biological bandages based on aquatic animals with a choice of treatment of 2° degree burns. Initiated the study of the use of xenograft of tilapia on second-degree burns about therapeutics and clinical surgical results. This is a systemic review of literature realized through article surveys on a database of Revista Brasileira de Burns, Revista Brasileira de Cirurgia Plastica, LILACS, and PubMed. Through the search on identified bases, 19 articles were considered eligible and underpin the construction of this review. In addition, the present study was based on literary works on semiology and dermatology and the Ministry of Health booklet on the emergency treatment of burns. Comparative research between human and Nile tilapia skin proves good results in histological, histochemical aspects, tensiometric properties, and manipulation related to the characteristics of this material. In addition, studies show that the use of biological occlusive dressings should reduce hydro electrolytic losses, avoid bacterial contamination, and promote reepithelialization of burned skin. Thus, it is concluded that xenografts be considered a solution in the therapeutic and socioeconomic scope of burns. It is, therefore, an innovative product, of easy application and high availability, which may become the first animal skin nationally studied and registered by the National Health Surveillance Agency.

Secondary systemic arterial hypertension (SAH) is a potentially curable disease. The pediatric population is the most affected. Due to the lack of deep investigation for secondary causes by health care professionals, many children end up living with the pathology without being diagnosed. Since SAH is a disease that evolves with lesions in several organs, treatment is expected to be carried out early, avoiding chronic health damage. The present research aimed to analyze the underdiagnosis of secondary SAH in children and its repercussion; describe the definition of secondary SAH; identify the main causes of secondary hypertension, and analyze forms of diagnosis and treatment. An integrative bibliographic review of secondary hypertension was carried out in children and adolescents between 2013 to 2022. Twenty-seven studies were chosen for this research. Studies have shown a significant degree of underrecognition of high blood pressure (BP) and hypertension, which is related to the steps needed to determine BP percentiles and the lack of SAH screening in pediatric consultations, which must be done through regular manual measurement of the blood pressure. All children with SAH should be investigated for secondary causes. If the diagnosis is confirmed, treatment of the underlying disease should be done by a specialist. Underdiagnosis of secondary hypertension is still very common since screening is not routinely performed in this age group. Therefore, strategies to improve the acceptance of guidelines should be prioritized.