Obesity is a major health hazard not only for developed countries but also for Bangladesh and it is an established risk factor of breast cancer. In our country there is a scarcity of studies on the associations of BMI and different features of breast tumour. This study was aimed to evaluate the associations of BMI with molecular sub-types, clinical and pathological characteristics of breast cancer in Bangladeshi women. This cross sectional descriptive type of observational study was conducted in National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka from September, 2019 to August, 2020. A total of 90 patients with breast cancer were selected purposively according to inclusion and exclusion criteria. An informed consent was sought from the patient to take part is this study. Detail history taking thorough physical examination was done along with relevant investigations. Data were collected by semi structured questionnaire and analysis was done with the help of Statistical Package for Social Science (SPSS), version 21.0. Mean age of the respondents was 41.17 years with a standard deviation of ±8.79 and a range of 24-65 years. Of all, ninety percent patients were housewives and 52.2% belonged to upper middle socio-economic class. About 66.7% patients were pre-menopausal and 33.3% were post-menopausal. The mean BMI of respondents was 25.89(±4.67) kg/m2 and among them 51.1% were obese, 23.3% were overweight and 20.0% had normal weight. No association between BMI and vii molecular subtypes of breast cancer were noted (p>0.05). No association between BMI and hormone receptor status of breast cancer was found. Association with tumor size, axillary lymph nodes, tumor grade and lymphovascular space invasion were also not significant (p>0.05). No association between BMI and molecular subtypes, clinical and pathological features of breast cancer were noted both in pre and post-menopausal groups. This study found no association between BMI and different features of tumor, which could be attributed to small sample size, absence of control and a single centered study. However, further extensive study is recommended.

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Objective Despite Bangladesh's high breast cancer prevalence (19.3 cases per 100,000 individuals), data are scarce regarding the reproductive epidemiology of breast cancer in Bangladesh. We investigated whether reproductive factors are associated with hormone receptor–positive breast cancer (Hr + BC) and triple-negative breast cancer (TNBC) in Bangladeshi women. Methods and Analysis In a tertiary hospital-based setting, we surveyed 1000 adult Bangladeshi females aged 18 or older. Of which 250 had TNBC, 250 had Hr + BC, and the remaining 500 were non-cancer individuals. Propensity score matching (PSM) was carried out to match the age and age of menarche of the potential 500 healthy individual with 250 TNBC and 250 Hr + BC individuals in separate estimates. The presence of TNBC or Hr + BC was the outcome variable, and the participants’ previous histopathology report confirmed it. We collected participants; detailed reproductive characteristics and demographics through a structured questionnaire. Those significant variables in the bivariate model were finally included in the adjusted multivariate multinomial logistic regression. Results The mean ages of participants in the Hr + BC, TNBC, and healthy groups were 44.96, 42.74 and 39.31 years, respectively. Adjusted binary multivariate logistic regression suggested that women living in rural areas with increased number of abortions, experiencing irregular menstruation, and consumption of hormonal contraceptives increased the risk for Hr + BC and TNBC compared to the healthy individuals. However, the magnitude of the risk varies across the types of breast cancer. One year increase in the age of menarche significantly increased the risk for Hr + BC by 1.71 times; however, it decreased the risk for TNBC by 30%. Conclusion Our findings imply that women's reproductive factors play a pivotal role in developing Hr + BC and TNBC; however, the degree of risk differs between the different types of breast cancer.

12060 Background: Geriatric oncology is a new concept worldwide, as well as in Bangladesh. Presently, there is a scarcity of data regarding the geriatric perspective of malignant patients in Bangladesh. Our study investigated the demographic differentiation, evaluation of symptoms burden on the basis of gender, and implications of the G8 questionaries in elderly cancer patients from a tertiary cancer care center in Bangladesh. This will help physicians to understand cancer in the elderly better, integrate their biological and epidemiological characteristics, and promote a longer life expectancy without compromising their quality of life in resource-constrained regions. Methods: This study included all the newly diagnosed and histologically confirmed primary solid tumors among age ≥60 years at the National Institute of Cancer Research & Hospital (NICRH), a tertiary care center in Bangladesh, during the year 2019 and 2020. For all statistical analyses, P<0.05 was considered significant. Results: Of 8057 solid tumor patients, 2823 were geriatric patients (35.04%). Male dominant patients' mean BMI was 20.23 ±SD 4.26 and 35.4% were malnourished. The low SES was 63.7%i and 68.5% of patients were illiterate. Pain was the most common symptom (37.44%), followed by GI symptoms (31.77%), whereas 33.1% suffered from more than one symptom. in the disease distribution, lung cancer was 52.4% irrespective of sex, followed by GIT 17% and HBS cancer 10%. Breast 24.58% and GIT 17.77% were the second most common malignancy in females and males, respectively. Among them, 22.1% of patients were metastatic at presentation and 25% had a comorbid condition. About 17.4% of patients were completely disabled. Low BMI with high ECOG status had more symptoms (p=.004). Gender, nutrition and socioeconomic condition strongly correlated with the patient's functional status and symptomatic presentation. Females were more comorbid with symptomatic metastases at presentation (p=0.020), and males presented with late-stage cancer (p=0.002). Compared to male elderly patients, female elderly patients suffered more from malnutrition and obesity (p=<.000). Polypharmacy rates for elderly males were lower than those for elderly females (p=0.000). Food intake behavior, weight loss, mobility, and health-related perception did not differ based on gender during or after treatment. Based on G8 scoring, we found that 12.3% were in the worse group, 70.2% in the intermediate group and the good group contained 17.5%. According to the cut-off value (≤11), 71.9% of patients needed the CGA evaluation. Conclusions: A high number of elder patients with multiple symptoms makes comprehensive management more challenging. A frail elderly patient's gender, SES, education, disease type, and stage along with performance status at the time of presentation of their disease are important prognostic factors.