This paper presents the results of an investigation using a new instrument for the study of brain damage in human subjects. The design of the instrument, the Continuous Performance Test (CPT) was based on certain electroencephalographic evidence which suggested that brain-damaged individuals should show inferior ability as compared with non-brain-damaged individuals on tasks requiring sustained attention or alertness.The waking EEGs of brain-damaged patients generally show either random bursts of hypersynchronous (high amplitude) activity intruding upon the normal activity of the brain, or a general hypersynchrony (3, 8). Hypersynchronous activity is also evident in 1 The authors would like to extend their appreciation to the following individuals and institutions for providing advice and/or subjects and testing facilities for this research: Mr. Samuel Greenhouse of the

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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Dysfunction of podocytes, cells critical for glomerular filtration, underlies proteinuria and kidney failure. Genetic forms of proteinuric kidney disease can be caused by mutations in several podocyte genes, including nephrin, a critical component of the kidney filter. In contrast, the etiology of acquired acute-onset nephrotic syndrome has remained elusive. Here we identify autoantibodies against nephrin in serum and glomeruli of a subset of adults and children with non-congenital acute nephrotic syndrome. Our findings align with published experimental animal studies and elucidate a novel autoimmune phenomenon in proteinuric kidney disease interfering with glomerular filter integrity.