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Background: Because of its nature, nursing is one of the stressful jobs. Abundant stressful factors existing in this job cause the occurrence of physical and mental disorders in nurses. Objectives: Therefore, the aim of this research was to determine the effect of health messages on job stress of nurses working in ICU (intensive care unit). Methods: This empirical study was performed in ICUs of hospitals in Babol city in 2015 -2016. The research population included all employed and eligible nurses working in ICUs of hospitals affiliated to Babol University of Medical sciences. After homogenization, the subjects were randomly divided into two groups of 40 named intervention and control groups. The tools for data collection included a demographic form and OSIPOW job stress questionnaire, which were completed by both groups. Then, for the nurses in the intervention group, 2 messages per week were sent regularly with a constant interval for three months. The OSIPOW questionnaire was completed by both groups one day and one month after the completion of the intervention. Statistical analysis was performed using SPSS v 20 software. Shapiro Wilk test was used to examine normal distribution of continuous quantitative variables. The data were evaluated using descriptive and inferential statistics (Mann Whitney and Freedman tests). Significance level was set at P < 0.05. Results:The nurses participating in this study were homogenously distributed in two groups in terms of job stress levels before