Background and Aim: Craniotomy is a surgery in which a flap of the skull is opened to access the affected area in the brain. Since paying attention to the aesthetic aspects of the patient’s head after surgery is very important for the patient’s mental health and social life, surgeons should try to adopt a method that minimizes damage to the scalp and follicles. Methods and Materials/Patients: In this clinical trial study, patients who were candidates for frontotemporoparietal craniotomy surgery were selected. Twenty-three selected patients were randomly divided into 2 groups consisting of a 12-member intervention group (L.G. Kempe) and an 11-member control group (Standard Reverse Question mark). Patients underwent a pre-operative biopsy of the scalp and a follow-up biopsy 6 months post-operatively. In the evaluation of aesthetic aspects, the created scar was scored using the Stony Brook Scar Evaluation Scale (SBSES). Patients were also directly asked about their satisfaction with the operation and the scar created. Results: In 23 patients, the results showed that patients who underwent LG Kempe incision craniotomy received significantly higher scores in SBSES scoring evaluations (P=0.005). There was no significant difference in subjective evaluations by asking patients about their satisfaction with the scar site and the operation area (P=0.75). In the analysis of post-operative hair follicle density between the 2 groups (P=0.910), general changes in pre-operative and post-operative follicle density in all samples (P= 0.657) as well as comparing the changes between 2 groups, no significant difference was found between follicular density changes between the intervention and control groups (P=0.137). Conclusion: Patients treated with L.G. Kempe incision had significantly higher SBSES scores, which can be considered an aesthetically superior method that could prevent the formation of undesirable scar.