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Perception and diagnosis of disorders by using single photon emission computed tomography (SPECT) image is difficult since this image does not contain anatomical Information. In the studies it is tried to make innovation SPECT image by magnetic resonance imaging (MRI) and image fusion methods. So the fused image is obtained involving functional and anatomical information. MRI image shows tissue brain anatomy and it has high spatial resolution without functional information. SPECT shows brain function and it has low spatial resolution. Fusion of SPECT and MRI images leads to a high spatial resolution image. The fused image with desired specifications consists in spatial and spectral distortions. Substitution methods such as IHS and Multi-resolution fusion methods such as wavelet transform preserve spatial and spectral information respectively.In This article we present a method that preserves both spatial and spectral information well and minimizes distortions of fused images relative to other methods.