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Blood sterilization systems irradiate blood with Gamma or X-ray radiation to prevent transfusion-associated graft versus host diseases (TA-GvHD).Present day irradiators use tags applied to the blood bags which change color when exposed to radiation of 25 to 50 Gy. This method is neither accurate nor efficient and results in considerable blood wastage.This thesis investigates alternative solutions that are low power, easy to handle, compact and efficient. A floating-gate (FG) metal-oxide semiconductor field effect transistor (MOSFET) is studied for its application as a radiation sensor. FG MOSFETs have been employed for this application, but never using an RF-CMOS (0.13 µm) process suitable for RF-ID wireless readout. This work studies device optimization for best possible performance in radiation dosimetry. Devices are fabricated with This journey would not have been possible without the unconditional love and support I received from my lovely wife, Ariane, and my parents.