BackgroundBecause computers are used in many aspects of today’s life, it seems necessary to include them in teaching and assessment processes.MethodThe aims of this cross-sectional study were to construct a multidimensional valid scale, to identify the factors that influenced the nature of student motivation on Computer Based Testing (CBT), to recognize how students self-regulated their activities around CBT, and to describe the efficiency of autonomous versus controlled situations on motivation. The study was carried out among 246 Iranian Paramedical Students of Tabriz Medical Sciences University, Tabriz, Iran; 2013–2014.The researchers prepared a questionnaire, based on the Self-Determination Theory (SDT), containing 26 items with a five-point Likert scale. It was prepared according to a previous valid questionnaire and by sharing opinions with some students and five professors. The factor analysis was done to perform instructional and exploratory factor analysis.ResultsThe Kaiser-Meyer-Olkin(KMO) measure was performed and variables were correlated highly enough to provide a reasonable basis for factor analysis. The selected 4 factors determined a 60.28% of the variance; autonomy 26.37%, stimulation 14.11%, relatedness10.71%, and competency 9.10%.ConclusionA questionnaire was prepared and validated, based on SDT variables. The results indicated that autonomous extrinsic motivation correlated positively with intrinsic motivation and CBT. There was a general positive attitude towards computer-based testing among students. As students became intrinsically motivated through the promotion of autonomous regulation, CBT was recommended as a proper test mode.Electronic supplementary materialThe online version of this article (10.1186/s12909-018-1249-4) contains supplementary material, which is available to authorized users.

Complex molecular changes that occur during prostate cancer (PCa) progression have been described recently. Whole genome sequencing of primary PCa samples has identified recurrent gene deletions and rearrangements in PCa. Specifically, these molecular events disrupt the gene loci of phosphatase and tensin homolog (PTEN) and membrane-associated guanylate kinase inverted-2 (MAGI2). In the present study, we analyzed the expression profile of MAGI2 gene in a cohort of clinical PCa (n = 45) and benign prostatic hyperplasia (BPH) samples (n = 36) as well as three PCa cell lines. We also studied the expression of PCa-related genes, including PTEN, NKX3.1, SPINK1, DD3, AMACR, ERG, and TMPRSS2-ERG fusion in the same samples. The expression of MAGI2 mRNA was significantly down-regulated in PC3, LNCaP and DU-145 PCa cell lines (p = 0.000), and also in clinical tumor samples (Relative expression = 0.307, p = 0.002, [95 % CI 0.002-12.08]). The expression of PTEN, NKX3.1, SPINK1, DD3, and AMACR genes was significantly deregulated in prostate tumor samples (p range 0.000-0.044). A significant correlation was observed between MAGI2 and NKX3.1 expression in tumor samples (p = 0.006). Furthermore, the inclusion of MAGI2 in the gene panel improved the accuracy for discrimination between PCa and BPH samples with the sensitivity and specificity of 0.88 [CI 0.76-0.95] and 0.83 [CI 0.68-0.92], respectively. The data presented here suggest that MAGI2 gene can be considered as a novel component of gene signatures for the detection of PCa.

Due to the frequent use and availability of the orthopantomogram (OPG), dental practitioners are more frequently confronted with incidental findings such as osteomas located in the maxillary/–mandibular bone or inside the maxillary sinuses. Osteomas are benign slow-growing osteogenic tumors, which frequently develop in the mandible. In the midface, osteomas appear frequently in the frontoethmoidal sinuses. Maxillary sinus osteoma is a rare entity. Also in asymptomatic patients, cranio-facial osteomas need to be further investigated for a precise diagnosis. The clinical importance of osteomas lies in their differentiation from a malignant lesion such as the osteosarcoma. In patients with multiple osteomas, Gardner's syndrome (GS) as an underlying disease needs to be excluded. In this report, we present the case of a solitary maxillary sinus osteoma, incidentally found on the OPG. The surgical technique for the removal of the osteoma is presented. In this case, the patient was free of the stigmas associated with GS.

Background: Multiple sclerosis (MS) as a chronic disease of the central nervous system have the very prevalent in worldwide. Its epidemiology is different region by region, and most of the geographical and environmental factors may play a role in its incidence. We designed this study to analyze demographic characteristics of MS. Methods: This survey has been conducted in East-Azerbaijan province, northwest of Iran. Prevalence of the MS has been measured using data from Committee for Diagnosis and Treatment of MS in 2014. Age, gender, and type of the disease also had been investigated in this research. Independent T-Test, Chi-square, Pearson and Fisher's exact test used to analyze data by SPSS21. Results: We had 2774 MS patients in 2014. Of them, 726 (26%) were male and 2003 (73%) were female. The mean age of males and females was 38±9 years and 37.09±9 years, respectively. The mean age of male patients significantly was higher than females (P=0.001). We measured 73.26 prevalence per 100000 populations in East-Azerbaijan province. Conclusion: Prevalence of the MS showed a significant increase in 5 years compared to previous studies. Because of disease's dishabilitating entity more interventional investigations are recommended to perform in preventing disease incidence or improving the quality of life of sufferers and increasing their life expectancy.

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