Cirrhosis is the common end stage of a number of chronic liver conditions and a significant cause of morbidity and mortality. With the growing epidemic of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide and will become one of the leading causes of cirrhosis. Increased awareness and understanding of NAFLD cirrhosis are essential. To date, there has been no published systematic review on NAFLD cirrhosis. Thus, this article reviews recent studies on the epidemiology, risk factors, clinical presentation, diagnosis, management, and prognosis of NAFLD cirrhosis.

Objective: Interstitial fluid flow through vascular adventitia has been disclosed recently. However, its kinetic pattern was unclear. Methods and Results:We used histological and topographical identifications to observe ISF flow along venous vessels in rabbits. By MRI in alive subjects, the inherent ISF flow pathways in legs, abdomen and thorax were enhanced by paramagnetic contrast from ankle dermis. By fluorescence stereomicroscopy and layer-by-layer dissection after the rabbits were sacrificed, the perivascular and adventitial connective tissues (PACT) along the saphenous veins and inferior vena cava were found to be stained by sodium fluorescein from ankle dermis, which coincided with the findings by MRI.By confocal microscopy and histological analysis, the stained PACT pathways were verified to be the fibrous connective tissues and consisted of longitudinally assembled fibers. By usages of nanoparticles and surfactants, a PACT pathway was found to be accessible for a nanoparticle under 100nm and contain two parts: a tunica channel part and an absorptive part. In real-time observations, the calculated velocity of a continuous ISF flow along fibers of a PACT pathway was 3.6-15.6 mm/sec. Conclusion:These data further revealed more kinetic features of a continuous ISF flow along vascular vessel. A multiscale, multilayer, and multiform "interstitial/interfacial fluid flow" throughout perivascular and adventitial connective tissues was suggested as one of kinetic and dynamic mechanisms for ISF flow, which might be another principal fluid dynamic pattern besides convective/vascular and diffusive transport in biological system.

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OSAHS children had a higher nocturnal BP than non-OSAHS children and dysregulation of BP control reflected by decreased nocturnal BP dipping. Frequency of oxygen desaturation, apneas, and obesity were related to BP.