The purpose of this study was to investigate the clinical application of severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) specific antibody detection and anti-SARS-CoV-2 specific monoclonal antibodies (mAbs) in the treatment of coronavirus infectious disease 2019 (COVID-19). The dynamic changes of SARS-CoV-2 specific antibodies during COVID-19 were studied. Immunoglobulin M (IgM) appeared earlier and lasted for a short time, while immunoglobulin G (IgG) appeared later and lasted longer. IgM tests can be used for early diagnosis of COVID-19, and IgG tests can be used for late diagnosis of COVID-19 and identification of asymptomatic infected persons. The combination of antibody testing and nucleic acid testing, which complement each other, can improve the diagnosis rate of COVID-19. Monoclonal anti-SARS-CoV-2 specific antibodies can be used to treat hospitalized severe and critically ill patients and non-hospitalized mild to moderate COVID-19 patients. COVID-19 convalescent plasma, highly concentrated immunoglobulin, and anti-SARS-CoV-2 specific mAbs are examples of anti-SARS-CoV-2 antibody products. Due to the continuous emergence of mutated strains of the novel coronavirus, especially omicron, its immune escape ability and infectivity are enhanced, making the effects of authorized products reduced or invalid. Therefore, the optimal application of anti-SARS-CoV-2 antibody products (especially anti-SARS-CoV-2 specific mAbs) is more effective in the treatment of COVID-19 and more conducive to patient recovery.

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For the dredging projects of inland river main channels in Jiangsu Province, the demand research of suitable dredging ship and dredging process schemes was carried out. Firstly, the development situation and trend of dredging vessels and processes were analysed. Secondly, combined with the current dredging methods commonly adopted in Jiangsu Province, the main dredging problems in the dredging process were discussed. Finally, on the basis of extensive investigation on the dredging environment and characteristics of inland river waterways in Jiangsu Province, considering technology, using, environmental protection and safety the overall design objectives of dredging ship and process schemes of inland river main channels in Jiangsu Province were put forward, and the design scopes and performance requirements of each target were given. The research results provided references for relevant dredging ship and process schemes design.

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