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Foot and mouth disease is a viral infection affecting cloven-hoofed domestic and wild animals. An outbreak of Foot and Mouth disease in vaccinated crossbred cattle was investigated at Adea berga and Welmera districts in 2017. A total number of 90 (27.19%) crossbred cattle were affected with FMD in the farms. The principal signs observed in clinically affected cattle were ropy salivation (39.6%) followed by vesicle formation (26.4%) respectively. The incidence was higher in non-vaccinated young stock (50%) and in female cows (43%) and the mortality proportion during the outbreak was 2.41%. The overall fatality proportion in non-vaccinated crossbred animals and in vaccinated female cows was 0.43% and 0.94% respectively. In FMD endemic areas, post-infection immunity is ranged from 15-30% which indicated post-infection immunity is unlikely a component of population immunity. The past or recent infections can be detected by induced antibodies against FMDV structural proteins.

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