Background Atherosclerosis is a process that causes coronary artery disease and is associated with the inflammatory response. In this study, we aimed to evaluate the association of Pan‐Immune‐Inflammation Value (PIV) with in‐hospital and long‐term mortality in STEMI patients. Methods A total of 658 patients who were admitted to the emergency department of two tertiary centers with the diagnosis of STEMI and underwent percutaneous coronary intervention (PCI) between 2018 and 2022 were retrospectively enrolled. PIV and other inflammation parameters were compared for the study population. The primary outcome was one‐year all‐cause of mortality. Results The mean age was 58.7 ± 17.1 years and 507 (76.9%) were male. The mean duration of the follow‐up was 18.8 ± 8.5 months (median 18.9 months). PIV was superior to the neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio, and systemic immune‐inflammation index for the prediction of primary and secondary outcomes in STEMI. Conclusion Our study reveals that PIV is a better predictor of mortality in STEMI patients. Prospective studies are needed to validate this biomarker.

Objective: It is to reveal the differences between clinical, angiographic, in-hospital and one-year follow-up results between young and elderly patients with acute ST-segment elevation myocardial infarction. Material and Methods: This study was designed retrospectively in two centers. 2891 patients were screened; 260 of which were young. 260 elderly patients were randomly selected among the patients and the differences between both groups were evaluated. Results: The median age of the young patients was 37 (34-39) years and the median age of the elderly patients was 65 (56-73) years, and male gender was dominant in both groups. Young patients were more likely to be admitted with Killip class 1, while older patients were more likely to be admitted with Killip class 2 (P=0.002). Single-vessel disease was more common in young patients (81.0% vs. 46.3%; P<0.001), while multi-vessel disease was more common in the elderly patients (19.0% vs. 53.7%; P<0.001). In one-year follow-up, all-cause hospitalization was lower in younger patients, but there was no significant difference in mortality between elderly and young patients. Conclusion: Young patients presenting with ST-segment elevation myocardial infarction were more frequent smokers, obese and dyslipidemic and although in-hospital outcomes were better than the elderly, one-year mortality was similar to those of the elderly.

Aim    The aim of this study was to investigate the relationship between left atrial (LA) abnormalities and ambulatory blood pressure variability (BPV) in heart failure with preserved ejection fraction (HFpEF) patients.Material and methods    In this single-center, prospective study, we included 187 patients with HFpEF. Eighteen patients with poor image quality were excluded from the study. BPV was evaluated using 24-h ambulatory blood pressure (BP) monitoring. The standard deviation of systolic BP (SBP-SD) was calculated to assess BPV. The patients were classified into two groups according to median SBP-SD (10.5 mm Hg).Results    Overall, 169 HFpEF patients (69.2% women, mean age 69.2±11 yrs) were evaluated. There were 98 patients (57.9%) with a SBP-SD greater than 10.5 mm Hg. Patients with higher SPB-SD had significantly higher left atrial stiffness (LASt) and lower LA reservoir strain (LASr) than those with low SPB-SD. LASt was correlated with 24 hr SBP-SD in both sinus rhythm (r= 0.35, p= 0.015) and atrial fibrillation patients (r= 0.32, p= 0.005). There were significant correlations between night-time SBP-SD and LASr (r=-0.23, p=0.045) in HFpEF with sinus rhythm. For all HFpEF patients, multiple regression analyses showed that 24-hr SBP-SD was correlated with LASt (coeff.=0.40, 95%CI= 0.52–5.25, P= 0.017).Conclusions    High BPV is associated with impaired LA function, especially for LASt and LASr. This study may provide insight for larger multicenter studies to evaluate the effects on outcomes in HFpEF.

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