Radiation therapy-induced skin ulcers are complex wounds that are unable to heal spontaneously. This affects the patient's quality of life and poses a major health problem. The most reliable curative treatment involves extensive debridement of the affected tissue and covering the wound with well-vascularized tissue. We report the case of a 76-year-old woman with a huge clavicle osteoradionecrosis ulcer that required complex resection and reconstruction with an extended vertical rectus abdominis myocutaneous flap.