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Nowadays there is a clear trend towards using methods and tools that can help to develop multiagent systems (MAS). This study presents a multiagent based middleware for the agents behavior simulation. The main challenge of this work is the design and development of a new infrastructure that can act as a middleware to communicate the current technology in charge of the development of the multiagent system and the technology in charge of the simulation, visualization and analysis of the behavior of the agents. It is a key element when considering that MAS are autonomous, adaptive and complex systems and provides advances abilities for visualization. The proposed middleware infrastructure makes it possible to visualize the emergent agent behaviour and the entity agent. It also allows visualization of the interaction between the agent and the environment.

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Abstract. This article presents a distributed agent-based architecture that can process the visual information obtained by stereoscopic cameras. The system is embedded within a global project whose objective is to develop an intelligent environment for location and identification within dependent environments that merge with other types of technologies. Vision algorithms are very costly and take a lot of time to respond, which is highly inconvenient if we consider that many applications can require action to be taken in real time. An agent architecture can automate the process of analyzing images obtained by cameras, and optimize the procedure.

CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low‐prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15‐year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research.