This chapter provides an overview of land use and land cover change in Key Messages• Land cover and land use within Florida have changed dramatically since pre-settlement times, primarily due to human activities, with significant impacts on ecosystems and biodiversity.• Climate-related impacts on land cover, resulting from human-caused climate change, have also been documented in Florida.• Patterns of historic land use and land cover change are important to quantify and visualize so that we can assess the degree to which natural systems have been impacted and changed by human activities.• Florida still has highly significant cultural and natural landscapes, which provide important services to people, in addition to possessing intrinsic values separate from their value to humans.• As future changes continue to occur as a result of climate change and population growth, it will be more important than ever to conduct careful land use planning and management so that we can preserve natural and cultural resources, and maintain the qualities that make Florida the special place that it is today.