It is important to diagnose epilepsy in a timely and accurate manner, and also to distinguish it from non-epileptic conditions. The present study was aimed at determining postictal serum prolactin levels and lactate dehydrogenase (LDH) activities in patients with new-onset seizure admitted to the emergency department in order to assess whether they could be used in the differentiation of epileptic seizure (ES) from nonepileptic seizure (NES). Eighty-five patients were included prospectively in this study. Patients were divided into 2 groups with respect to epilepsy diagnosis, and the final groups were comprised of 36 patients with ES and 49 patients with NES. Blood samples were obtained within 1 hour of seizure. No significant differences between groups were observed in prolactin levels and in the percentage of patients with abnormal prolactin level ( P = .569 and .239, respectively). The median LDH activity was significantly higher in those with ES compared with those with NES ( P = .031). The percentage of patients with elevated LDH levels was similar between 2 groups ( P = .286). This was the first study to examine LDH activities in terms of its role in differentiation of seizure origin in the postictal period in patients hospitalized with seizure. Our study demonstrated that serum LDH activities within 1 hour after the seizure appear to be increased in patients with ES compared with those with NES, suggesting the potential role of LDH activities as a diagnostic tool in distinction of seizure types. Our study supports the hypothesis that LDH-antagonists may have a role in the management of seizure and epilepsy.

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Objectives: To investigate whether confusion, respiratory rate, shock index-age ≥65 years (CRSI-65) score, consisting of basic physiological parameters, can be used for severity prediction in patients with community-acquired pneumonia. Methods: This is a prospective cohort and singlecenter study conducted in Bolu Abant Izzet Baysal University Hospital, Bolu, Turkey between January 2018 and June 2018. The study investigated CRSI-65 score in predicting 4-week mortality and the need for intensive care for patients with community-acquired pneumonia. Results: A total of 58 patients with communityacquired pneumonia admitted to the emergency Original Article department were included in this study. Of the patients, 62.1% were males (n=36), and the mean age of the patients was 72.87 ± 12.30 years. After 4 weeks of follow-up, CURB-65 and CRSI-65 scores showed similar results in predicting mortality with respect to specificity, sensitivity, and positive and negative predictive values. Area under the receiver operating characteristic curve was 0.926 for the CURB-65 (95% confidence interval [CI] 0.853-0.999) and 0.954 for the CRSI-65 (95% CI 0.899-0.999). Conclusion: Similar to the CURB-65 score, the CRSI-65 score appears to be useful in predicting 4-week mortality. The evaluation of CRSI-65 score can be used in emergency department triage, primary care, and non-hospital settings.

GİRİŞ ve AMAÇ: İnme, kardiyovasküler hastalıklar ve kanserlerden sonra üçüncü en yaygın ölüm nedenidir. CRP ve tam kan sayımı parametrelerinin iskemik ve hemorajik inmenin erken ayrımında rolü olup olmadığını araştırdık. YÖNTEM ve GEREÇLER: Arşiv kayıtlarını kullanarak retrospektif bir çalışma yaptık. 5 Kasım 2015 ile 5 Kasım 2017 tarihleri arasında iskemik veya hemorajik inme tanısı alan hastalar çalışmaya dahil edilmiştir. Dahil edilen hastaların demografik verileri, temel semptom ve bulguları, bilgisayarlı tomografi ve manyetik rezonans görüntüleme sonuçları elde edildi. Hastaların trombosit sayısı, ortalama trombosit hacmi, hemoglobin konsantrasyonu, ortalama korpüsküler hacmi, beyaz küre sayısı ve C -reaktif protein sonuçları kayıt altına alınmıştır. BULGULAR: Çalışmaya dahil edilen 100 hastanın 68'inde (% 68) iskemik inme vardı. Kalan 32 (% 32) hastaya hemorajik inme tanısı kondu. Kadınlarda ortalama yaş 75.35 ± 1.7, erkeklerde 71.06 ± 1.9 idi. Hemorajik inmeli hastalarda iskemik inmeli hastalara göre ortalama trombosit hacmi (p = 0,009) ve beyaz küre sayısı (p = 0,006) daha yüksekti ve istatistiksel olarak anlamlı çıkmıştır. TARTIŞMA ve SONUÇ: Ortalama trombosit hacmi ve beyaz kan hücresi sayısı hemorajik inmede daha yüksek görünse de, daha bilgilendirici sonuçlar için daha ileri çalışmalara ihtiyaç vardır.

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