In the world, a million adults have peripheral artery disease (PAD), a number that is likely to escalate as the population ages. Lower-extremity PAD is a component of systemic atherosclerosis and confers a markedly heightened risk of cardiovascular morbidity and mortality. Material and Methods: Recruited 48 patients Exercise therapy combined with Nordic Walking and cyclette program in patients with PAD second IIA Stage Leriche Fontaine scale stable for at least six months, with interval free running (IML) between 200 and 300 meters. Result: In Group A the free shift range test (IML) 137 ± 12 meters in T0, resulting in statistically significant post processing T1 222 ± 10 (p < 0.05). In Group B T0 138 ± 6 meters in T1 IML 212 ± 10 meters (p < 0.05). The results obtained in this study showed that the two types of exercise, at least after a short training period, are similar in terms of increasing the autonomy of the way and improving the quality of life (QoL). Conclusion: The benefits of regular physical activity and comprehensive secondary prevention have the potential to benefit patients with PAD by preserving or improving functional capacity and reducing cardiovascular events.