Experimental research concerning fear and anxiety often involves exposing human subjects to fear-cue stimuli. Several aspects of fear-cue exposure may generate ethical concerns on the part of institutional review boards (IRBs) charged with protecting human research participants from harm. The goal of this article is to provide researchers with a framework for effectively addressing ethical concerns raised by some fear and anxiety research. We highlight the ethical considerations raised by fear-cue exposure procedures, review the extant research literature relevant to these concerns, make recommendations on how to address IRB ethical concerns, and recommend various research strategies that might clarify the impact (positive or negative) of fear-cue exposures on human subjects participating in anxiety research. IRBs may raise a variety of important concerns about fear-cue exposure research. Some of these concerns can be addressed by adequate justification within the IRB protocol using existing research findings. Further research is needed to address a variety of potential ethical concerns. Such research may help address concerns regarding research involving fear-cue exposure.

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