hippocampus of schizophrenia patients in post-mortem studies. 5 Furthermore, DISC1 has previously been shown to directly regulate the GSK3ß signalling pathway with downstream effects on neurogenesis. 6 NRG1-ErbB signalling is also known to interact with the Wnt-GSK3ß signalling pathway, 4 and genetic variants altering NRG1 expression have been implicated in a range of neuropsychiatric disorders. 3 Recently Makinodan et al. 7 have shown that prolonged social isolation in mice during the juvenile period (PND 21-35) resulted in decreased Type III neuregulin expression in the prefrontal cortex and impaired oligodendroctye development and myelination. Here we show that even a relative brief exposure to non-social stressors during the juvenile period is sufficient to produce a selective decrease in NRG1 Type III expression. Taken together, these findings suggest that a wide range of pre-pubertal stressors can produce long-lasting effects on the expression of psychiatric risk genes, with significant implications for brain myelination and development and risk for later psychiatric disorder.