In this research, we have conducted a cost-effectiveness analysis to examine the relative importance of vaccination and self-isolation, with respect to the current H1N1 outbreak. We have developed a continuous-time simulation model for the spread of H1N1 which allows for three types of interventions: antiviral prophylaxis and treatment, vaccination, and self-isolation and mandatory quarantine. The optimization model consists of two decision variables: vaccination fraction and self-isolation fraction among infectives. By considering the relative marginal costs associated with each of these decision variables, we have a linear objective function representing the total relative cost for each control policy. We have also considered upper bound constraints for maximum number of individuals under treatment (which is related to surge capacity) and percentage of infected individuals (which determines the attack rate). We have used grid search to obtain insight into the model, find the feasible region, and conduct the costeffectiveness analysis.

Summer flounder is a new aquaculture species, the culture of which could be made simpler by the replacement, to the greatest extent possible, of live feed with formulated diets. Previous work has shown that development of the summer flounder stomach can be accelerated by treatment of the larvae with thyroid hormone. Two series of experiments were conducted. In the first experiment, 2‐week feeding trials were conducted beginning with fish (which were not treated with thyroid hormone) 14, 21, 28, 35, or 42 days after hatch (DAH) to determine when they could begin to utilize commercially available formulated diets. In the second experiment, two groups of sibling larvae, one treated with thyroid hormone, the other not, were placed in similar 2‐week feeding trials at 25, 30 or 35 DAH to test whether survival of thyroid hormone‐treated larvae would surpass those of untreated larvae. The first series of experiments demonstrated that the larvae could not effectively utilize the formulated diets until 35 DAH. The second series of experiments indicated that thyroid hormone‐treated larvae do not exhibit significantly greater survival than untreated larvae.