Objective: To assess the effect of Remedisvir, its safety Profile, and efficacy among COVID-19 patients. Study Design: Retrospective Observational study. Setting: South East Hospital and Research Center, Islamabad, Pakistan. Period: December 2020 to July 2021. Material & Methods: 100 patients were included in this study who received Remedisvir infusion, day 5, 7, and 10 after admitting the hospital with COVID-19 symptoms. We infuse 200mg I/V Remedisvir in 100cc N/S followed by 100mg I/V daily into 100cc N/S. After infusion, all patients were monitored strictly. Results: The mean age of the patients was (51. 89±15.441). The outcome of Remedisvir showed that 14% improved their condition, 42% discharged with oxygen, 27% discharged without oxygen, and only 17% expired). Remedisvir showed a positive effect at (p≤0.001) among laboratory values and oxygen support category. Conclusion: When patient suffering from COVID-19 symptoms and low oxygen saturation show good clinical outcome treated with Remedisvir. According to the results of our study, it is concluded that, at present Remedisvir remains a good drug, it shows a positive effect on oxygen saturation and length of hospital stay.

Objective: Musculoskeletal discomfort is common in people working in poor ergonomic designs with prolonged poor posture. The main purpose of this study was to compare the postural discomfort among right and left-handed university students of Rawalpindi/Islamabad. Methodology: A cross-sectional survey was carried out using standardized Nordic Musculoskeletal Discomfort Questionnaire. Samples were collected by simple convenient sampling technique from 221 students (53.8% females and 46.2% Males) comprising of 110 left and 111 right-handed University students. Results: The comparison of percentages among left and right-handed participants at hip, knee and ankle were as follows: hip (left-handed 19% and 5.42% right-handed), knee (left-handed 17.19%, right-handed 9.04%), ankle (left-handed 9.50%, right-handed 8.14%). The prevalence of chronic musculoskeletal discomfort was significant in left-handed participants as compared to right-handed participants. The highest frequency of discomfort was found in the neck and shoulder region of left-handed participants. Chi square test showed a significant difference in frequencies of discomfort in left and right-handed participants (p<0.01), whereas there was as such no significance in ankle region (p>0.05). Conclusion: Postural discomfort was more prevalent among left-handed university students as compare to right-handed students. The highest frequency of discomfort was found in the neck and shoulder region of left-handed participants. Further research and attention should be directed towards the relation of handedness with musculoskeletal discomfort and factors influencing postural discomfort in left-handed students.

Background: Piriformis syndrome (PS) has negative impact on the daily activities of the patients and lead to disability. There is an anatomical association of piriformis muscle with sacroiliac joint (SIJ). So manual therapy including manipulation of SI joint may be the option for relieving the symptoms of PS Objective: To investigate the effectiveness of Sacroiliac joint manipulation in improving pain pressure threshold in patients with chronic piriformis syndrome. Materials and Methods: A randomized clinical trial (NCT04603703) was conducted at Max Rehab and Physical Therapy Centre G8-Markaz, Islamabad, Pakistan. A total of n=30 patients were randomly divided into Experimental group (n=15) and control group (n=15). Both groups received conventional physical therapy including therapeutic ultrasound, moist hot pack, piriformis muscle stretching, myofascial release of paraspinal muscles, gluteal strengthening, sciatic neurodynamics. The experimental group additionally received sacroiliac joint manipulation. The outcome measures were pain, straight leg raise (SLR), pain pressure threshold and piriformis muscle length. The total time frame of the treatment was 3 days per week for 6 weeks and pre and post intervention assessment was done. Result: The mean age of participants was 40.46 ±10.513 years. Pain, SLR, pain pressure threshold and piriformis length was significantly improved (p<0.001) in both the experimental and control group after 6th week intervention. Between group comparison there was no significant difference between the groups after 6-week intervention regarding the pain, SLR and piriformis muscle length, except pain pressure threshold which was significantly improved in experimental group as compared to control group (67.7±18.42 vs 52.51±15.26, p=0.020) . Conclusion: Addition of the sacroiliac joint thrust manipulation technique and conventional physical therapy alone were equally effective in decreasing pain intensity and normalizing length of Piriformis and Straight leg raise. But SIJ manipulation showed promising results on pain pressure threshold. Keywords: Articular, physical therapy modalities, piriformis muscle syndrome, pain threshold, range of motion, sacroiliac joint.