We analyze a novel multi-level version of a recently introduced compressed sensing (CS) Petrov-Galerkin (PG) method from [H. Rauhut and Ch. Schwab: Compressive sensing Petrov-Galerkin approximation of high-dimensional parametric operator equations, Math. Comp. 304(2017) 661-700] for the solution of many-parametric partial differential equations. We propose to use multi-level PG discretizations, based on a hierarchy of nested finite dimensional subspaces, and to reconstruct parametric solutions at each level from level-dependent random samples of the high-dimensional parameter space via CS methods such as weighted ℓ 1 -minimization. For affine parametric, linear operator equations, we prove that our approach allows to approximate the parametric solution with (almost) optimal convergence order as specified by certain summability properties of the coefficient sequence in a general polynomial chaos expansion of the parametric solution and by the convergence order of the PG discretization in the physical variables. The computations of the parameter samples of the PDE solution is "embarrasingly parallel", as in Monte-Carlo Methods. Contrary to other recent approaches, and as already noted in [A. Doostan and H. Owhadi: A non-adapted sparse approximation of PDEs with stochastic inputs. JCP 230(2011) 3015-3034] the optimality of the computed approximations does not require a-priori assumptions on ordering and structure of the index sets of the largest gpc coefficients (such as the "downward closed" property). We prove that under certain assumptions work versus accuracy of the new algorithms is asymptotically equal to that of one PG solve for the corresponding nominal problem on the finest discretization level up to a constant.