Background. Environmental impacts from informal e-waste recycling are increasing in Africa. E-waste handling and disposal exposes people to highly toxic cocktails of heavy metals, brominated flame retardants, non-dioxin-like polychlorinated biphenyls (PCB), polycyclic aromatic hydrocarbons (PAH), polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PBDF) and dioxin-like polychlorinated biphenyls (DL-PCB). Most of these compounds are endocrine disrupters, and most are neuro-and immune-toxic as well. Objectives. Informal e-waste recycling in African countries is a serious public health threat. The present paper reviews the extent of e-waste exposure in Africa and related impacts on people, animals and the environment. Methods. Four electronic databases (PubMed, Science Direct, Scopus, Google Scholar) were searched for publications related to e-waste and human health in Africa. Search terms included 'e-waste in Africa' , 'e-waste in developing nations' , 'public health and e-waste' , 'environment and e-waste' , and 'e-waste and health'. Discussion. Elevated levels of e-waste pollutants in water, air, soil, dust, fish, vegetable, and human matrices (blood, urine, breast milk) indicate that not only are e-waste workers at risk from exposure to e-waste, but the general population and future generations as well. Headache, cough and chest pain, stomach discomfort, miscarriage, abnormal thyroid and reproductive function, reduction of gonadal hormone, and cancer are common complaints of those involved with the processing of e-waste. Conclusions. The evidence presented from the reviewed studies illustrates the extent of the human health and environmental risks posed by e-waste in Africa. There is a need for a regulatory framework including specific legislation, infrastructure and protocols to safely recycle and dispose of e-waste in sub-Saharan African countries.