In fish production systems, Aeromonas hydrophila and Flavobacterium columnare have been found to readily form biofilms on fish mucosal surfaces and any number of inanimate substrates (Cai & Arias, 2017;Cai et al., 2019). Recent in vitro work has demonstrated that the presence of different teleost fish mucus extracts upregulates pathways associated with robust F. columnare biofilm development (Lange et al., 2018(Lange et al., , 2019. The persistence of A. hydrophila and F. columnare within production systems could lead to continuous disease problems (Hossain et al., 2014;Mohammed & Arias, 2014), as well as contribute to the potential overuse of therapeutics and, ultimately, to an increased incidence of antibiotic resistance among pathogens