Far ultraviolet to far infrared images of the nearby galaxy NGC 5194 (M51a), from a combination of space-based (Spitzer, GALEX, and Hubble Space Tele-1 Based on observations obtained with the Spitzer Space Telescope and with GALEX.

Our findings suggest that acute alcohol consumption has dual anti-inflammatory effects that involve augmentation of IL-10 and attenuation of monocyte inflammatory responses involving inhibition of NF-kappaB. These mechanisms may contribute to the beneficial effects of moderate alcohol use on atherosclerosis.

Role of lymphoid organ spheroids in chronic Taura syndrome virus (TSV) infections in Penaeus vannamei Kenneth W. asso on'^', Donald V. ~i g h t n e r~, Leone L. ~o h n e y~, Rita M. ~e d m a n~,

The Taura syndrome virus (TSV) disease cycle was redefined through histological and gene probe analysis of experimentally infected specific pathogen-free (SPF) Penaeus vannamei sampled at timed intervals. The cycle consists of 3 overlapping, but clinically and histologically distinct, phases: a -7 d peracute to acute phase, a -5 d transition phase (previously termed the chronic or recovery phase), and a definitive chronic phase. The acute phase is characterized by the rapid development of severe, multifocal to diffuse cuticular epithelial necrosis and high mortalities. Using in situ hybridization analysis, infected pre-lytic cuticular epithelial cells display very strong TSV-positive probe signals, and a total of 3 stages of acute phase necrosis are described. Surviving P. vannamei then enter the transition phase, which is distinguished histologically by multifocal melanized lesions within regions of the cuticular epithelium (resolving acute phase lesions), focal active acute phase lesions, and the onset of lymphoid organ (LO) spheroid development. Gene probe analysis of transitionally infected shrimp reveals probe-positive foci of active acute phase lesions, a diffuse probe signal within the walls of morphologically normal L 0 tubules and/or focal probe signals within developing L 0 spheroids. Shrimp surviving this stage enter the chronic phase infection after ecdysis. The defining characteristics of the chronic phase include the cessation of mortalities, the resumption of normal behavioral patterns, the con~plete absence of v~sible melanized lesions and acute phase histological lesions of the cuticular epithelium, and marked L 0 hypertrophy directly resulting from the rapid development of numerous L 0 spheroids, some of which are TSV positive by in situ hybridization analysis.

Over the past two years the Ubicomp vision of ambient voice assistants, in the form of smart speakers such as the Amazon Echo and Google Home, has been integrated into tens of millions of homes. However, the use of these systems over time in the home has not been studied in depth. We set out to understand exactly what users are doing with these devices over time through analyzing voice history logs of 65,499 interactions with existing Google Home devices from 88 diverse homes over an average of 110 days. We found that specific types of commands were made more often at particular times of day and that commands in some domains increased in length over time as participants tried out new ways to interact with their devices, yet exploration of new topics was low. Four distinct user groups also emerged based on using the device more or less during the day vs. in the evening or using particular categories. We conclude by comparing smart speaker use to a similar study of smartphone use and offer implications for the design of new smart speaker assistants and skills, highlighting specific areas where both manufacturers and skill providers can focus in this domain.